antioxidant

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Phytochemical Analysis, Quantitative Estimations of Total Phenols and Free Radical Scavenging Activity of Bupleurum subovatum from Jerusalem

Journal Title, Volume, Page: 
Pharmaceutical Sciences 2015;21(4):205-21010.15171/PS.2015.38
Year of Publication: 
2016
Authors: 
Nidal Jaradat
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Ahmad Eid
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Fatima Abdelwahab
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Linda Isa
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Amjad Abdulrahman
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Murad Abualhasan
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Azmi Mahmoud Ali Hussein
Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

The crude extracts from Bupleurum subovatum plant were used to screen the presence of secondary metabolic products, to estimate the total phenol content and free radical scavenging activity for the plant extracts.  Methods:Antioxidant activity was evaluated by using 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay, while total phenol content was determined by using Folin Ciocalteu' s method. Result:The phytochemical analysis confirmed the presence of phenol, proteins, starch, reducing sugars, tannins, volatile oils, cardiac glycosides, steroid, and huge amounts of saponins. Total phenolic content in the methanolic extract was 9.05 mg/g Gallic acid. At the same time, methanolic extract showed a mild potential oxygen free radical scavenging ability as well as the IC50 for the plant was 18.60 ± 0.36 µg/ml, which justified its uses in the folkloric medicine and could be further subjected for the isolation of their therapeutic active compounds. Conclusion:The results of this study revealed the antioxidant activity and confirmed the therapeutic usage of Bupleurum subovatum in the traditional medicine.

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Synthesis and Biological Activities of a Novel Naringin Based Heterocyclic Derivatives

Journal Title, Volume, Page: 
Jodeh & al. / Mor. J. Chem. 3 N°X (2015) 242-250
Year of Publication: 
2016
Authors: 
Shehdeh Jodeh
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Nuha Abdel Rahman Shawarb
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Nidal Amin Jaradat
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Ismail Warad
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Fatima Mohammed Hussen
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Motasem Almasri
Department of Biology, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Rachid Salghi
Laboratory of Applied Chemistry and Environment , ENSA, Ibn Zohr University, PO Box 1136, 80000 Agadir, Morocco
Preferred Abstract (Original): 
A number of  naringin based heterocyclic derivatives dioxolan e and  imidazolidin e have been synthesized and  evaluated for their  antioxidant and  biological activi ties. The chemical structures of the newly synthesized  compounds were verified on the basis of spectral  and elemental methods of analysi s. Investigation of  antibacterial  activity of the se compounds w as determined by measuring  MIC value using  broth micro d ilution method for G ram - positive and Gram - negative bacteria , among th e various synthesized compounds. D ioxolane  showed the highest antibacterial activity with  minimal inhibitory concentration (MIC) of 0. 125 mg/ml ,  in  addition this compound exhibit the best antioxidant activity with inhibition concentration ( IC 50 ) of 18.7 μg/mL , compared with other semi synthetic derivative .
warad's picture

Synthesis and Biological Activities of a Novel Naringin based Heterocyclic Derivatives

Journal Title, Volume, Page: 
Moroccan Journal of Chemistry, 3(1) 242-250
Year of Publication: 
2016
Authors: 
Shehdeh Jodeh
Corresponding author, E-mail: [email protected] (S. Jodeh) Received 26 Dec 2015, Revised 11 Jan 2016, Accepted 20 Jan 2016
Current Affiliation: 
Department of Chemistry, An-Najah National University, Nablus, Palestine
Nuha Shawarb
Current Affiliation: 
Department of Chemistry, An-Najah National University, Nablus, Palestine.
N.Jaradat
Current Affiliation: 
College of Pharmacy, An-Najah National University, Nablus, Palestine
I.Warad
Current Affiliation: 
Department of Chemistry, An-Najah National University, Nablus, Palestine.
F.Hussein
Current Affiliation: 
College of Pharmacy, An-Najah National University, Nablus, Palestine
M.El-Masri
Current Affiliation: 
Department of Biochemistry, Genetics Laboratory An-Najah National University, Nablus, Palestine
R.Salghi
Current Affiliation: 
Laboratory of Applied Chemistry and Environment, ENSA, Ibn Zohr University, PO Box 1136, 80000 Agadir, Morocco
Preferred Abstract (Original): 
A number of naringin based heterocyclic derivatives dioxolane and  imidazolidine have been synthesized and evaluated for their antioxidant and biological activities. The chemical structures of the newly synthesized compounds were verified on the basis of spectral and elemental methods of analysis. Investigation of antibacterial activity of these compounds was determined by measuring  MIC value using broth micro dilution method for Gram-positive and Gram-negative bacteria, among the various synthesized compounds. Dioxolane showed the highest antibacterial activity with minimal inhibitory concentration (MIC) of 0.125mg/ml, in addition  this compound exhibit the best antioxidant activity with inhibition concentration (IC50) of 18.7 μg/mL, compared with other semi synthetic derivative
adhamtaha's picture

Bioactivity of Viscum album extracts from Olive and Almond host plants in Palestine

Journal Title, Volume, Page: 
Pharmacognosy Journal 6(2):38-44 · February 2014 DOI: 10.5530/pj.2014.2.7
Year of Publication: 
2014
Authors: 
Murad Abualhasan
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Nidal Jaradat
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Nael Abu-Hasan
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Motasem Almasri
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Adham Abu Taha
Department of Bio-Medical Sciences, Division of Pharmacology and Toxicology, An-Najah National University, Nablus-Palestine
Current Affiliation: 
Department of Biomedical Sciences, Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine
Ahmad Rabbaa
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Noor Natsheh
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Sajed Shalalfe
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Majdi Najib
Pharmacy Directorate, MoH-Palestine
Preferred Abstract (Original): 

Introduction:Viscum album is a semi-parasitic medicinal plant which has been used for many years as a remedy in traditional medicine. The plant is widely used in folk medicine in Palestine; mainly in the treatment of cancer, diabetes and heart disease. Since no previous reports on bioactivity of this plant in association with host plant specificity in Palestine, the current study aimed at evaluating bioactivity of almond and olive variants of this plant. Method: Methanolic extract of viscum album cultivated from almond and olive host plants were tested for antioxidant, antimicrobial . Prothrombin time (PT) and activated partial thromboplastin time (aPTT) were also used to assess anticoagulant activities of plant extracts. Result: The result demonstrated that Viscum album have an IC50 of 25.34±3.8μg/ml when hosted by olive while the IC50 was 15.37±2.2μg/ml when hosted by almond. Crude extracts of both Viscum album plants showed strong inhibition effects on the growth of the studied Staphylococcus aureus strains (ATCC 25923 and MRSA) with a pronounced effect when extracts of almond host was used. However, the effects of both host extracts were very limited or absent when tested against Gram-negative reference and clinical strains. Plant extracts of both host showed prolonged PT and PTT compared to phosphate buffered saline control solution. Conclusion: In conclusion, variations in the bioactivity of Viscum album is clearly influenced by host type and further studies required to illustrate such variations using other host plants.

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Nidal Zatar's picture

Synthesis of Novel Biologically Active Mono Acid Esters Derived From The Constituents of Urtica Pilulifera

Journal Title, Volume, Page: 
Iranian journal of pharmaceutical research (IJPR) 01/2013; DOI:ID: 5287-IJPR
Year of Publication: 
2014
Authors: 
Ahmad Husein
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Waheed Jondi
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Mohammed Ali-Shtayeh
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Nidal A. Zatar
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

New mono acid esters have been synthesized from the reaction of benzoic acid and mono-hydroxybenzoic acids with 2-phenoxyethanol separated from Urtica pilulifera, characterized, and screened for possible antioxidant, antifungal, antimicrobial and anticancer activities. 2-phenoxyethyl 4-hydroxy benzoate showed considerable activity against MCF-7 with IC50 is less than 62.5 µg/ml, and complete inhibition at a concentration less than 37.5 µg/ml against M. canis and less than 50 µg/ml against T. rubrum. On the other hand 2-phenoxyethyl 2-hydroxy benzoate reveals 70% of gentamicin against K. pneumoniae.

ahmadhusseinahmad's picture

Synthesis of Novel Biologically Active Mono Acid Esters Derived From The Constituents of Urtica Pilulifera

Journal Title, Volume, Page: 
Iranian journal of pharmaceutical research (IJPR) 01/2013; DOI:ID: 5287-IJPR
Year of Publication: 
2014
Authors: 
Ahmad Husein
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Waheed Jondi
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Mohammed Ali-Shtayeh
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Nidal A. Zatar
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

New mono acid esters have been synthesized from the reaction of benzoic acid and mono-hydroxybenzoic acids with 2-phenoxyethanol separated from Urtica pilulifera, characterized, and screened for possible antioxidant, antifungal, antimicrobial and anticancer activities. 2-phenoxyethyl 4-hydroxy benzoate showed considerable activity against MCF-7 with IC50 is less than 62.5 µg/ml, and complete inhibition at a concentration less than 37.5 µg/ml against M. canis and less than 50 µg/ml against T. rubrum. On the other hand 2-phenoxyethyl 2-hydroxy benzoate reveals 70% of gentamicin against K. pneumoniae.

waheedjj's picture

Synthesis of Novel Biologically Active Mono Acid Esters Derived From The Constituents of Urtica Pilulifera

Journal Title, Volume, Page: 
Iranian journal of pharmaceutical research (IJPR) 01/2013; DOI:ID: 5287-IJPR
Year of Publication: 
2014
Authors: 
Ahmad Husein
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Waheed Jondi
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Mohammed Ali-Shtayeh
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Nidal A. Zatar
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

New mono acid esters have been synthesized from the reaction of benzoic acid and mono-hydroxybenzoic acids with 2-phenoxyethanol separated from Urtica pilulifera, characterized, and screened for possible antioxidant, antifungal, antimicrobial and anticancer activities. 2-phenoxyethyl 4-hydroxy benzoate showed considerable activity against MCF-7 with IC50 is less than 62.5 µg/ml, and complete inhibition at a concentration less than 37.5 µg/ml against M. canis and less than 50 µg/ml against T. rubrum. On the other hand 2-phenoxyethyl 2-hydroxy benzoate reveals 70% of gentamicin against K. pneumoniae.

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Phytochemistry, Pharmacological Properties and Industrial Applications of Rhus coriaria L. (Sumac ): A Review

Journal Title, Volume, Page: 
Jordan Journal of Biological Sciences (JJBS) 12/2014; volume 7(4):233 - 244
Year of Publication: 
2014
Authors: 
Ibrahim M. Abu-Reidah
Biodiversity and Biotechnology Research Unit, Biodiversity and Environmental Research Center-BERC, Til, Nablus, Palestine
Rana M. Jamous
Biodiversity and Biotechnology Research Unit, Biodiversity and Environmental Research Center-BERC, Til, Nablus, Palestine
Mohammed S. Ali-Shtayeh
Biodiversity and Biotechnology Research Unit, Biodiversity and Environmental Research Center-BERC, Til, Nablus, Palestine
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Rhus coriaria L. (Sumac), belonging to the Anacardiaceae family, is an important and most used species of the genus Rhus in the Mediterranean region since antiquity. Sumac has long been used as a flavoring spice, drink, appetizer, and as acidulant in food recipes; in addition to its use in traditional medicine. The role of plant in leather and textile industry is also significant. R. coriaria is very rich in phenolics mainly, tannins and flavonoids, in addition to its abundance in organic acids. The leaves and fruits of R. coriaria are recognized to have defensive and beneficial effects on a wide set of diseases including, but not limited to, diabetes mellitus, cancer, stroke, oral-diseases, inflammation, diarrhea, and dysentery. On the other hand, Sumac extracts were found to possess a potential antiviral, antimicrobial, antifungal, antioxidant and hypolipidemic activities. This review updates the current phytochemical, biological and therapeutic knowledge so far exist on R. coriaria. It also aims at highlighting the importance of Sumac extracts as a promising and potential source of functional ingredients and nutriceuticals with desirable bioactivities, prompting the further use of Sumac in food preservation, pharmacology and functional food industries.

MSShtayeh's picture

Synthesis of Novel Biologically Active Mono Acid Esters Derived From The Constituents of Urtica Pilulifera

Journal Title, Volume, Page: 
Iranian journal of pharmaceutical research (IJPR) 01/2013; DOI:ID: 5287-IJPR
Year of Publication: 
2013
Authors: 
Ahmad Husein
Waheed Jondi
Mohammed Ali-Shtayeh
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Nidal Zatar
Preferred Abstract (Original): 

New mono acid esters have been synthesized from the reaction of benzoic acid and mono-hydroxybenzoic acids with 2-phenoxyethanol separated from Urtica pilulifera, characterized, and screened for possible antioxidant, antifungal, antimicrobial and anticancer activities. 2-phenoxyethyl 4-hydroxy benzoate showed considerable activity against MCF-7 with IC50 is less than 62.5 µg/ml, and complete inhibition at a concentration less than 37.5 µg/ml against M. canis and less than 50 µg/ml against T. rubrum. On the other hand 2-phenoxyethyl 2-hydroxy benzoate reveals 70% of gentamicin against K. pneumoniae.

7413's picture

A Validated HPLC Determination of the flavone Aglycone Diosmetin in Human Plasma

Journal Title, Volume, Page: 
Biomedical Chromatography Volume 18, Issue 10, pages 800–804
Year of Publication: 
2004
Authors: 
Feras Imad Kanaze
Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Current Affiliation: 
Department of Pharmacy,Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine
Melpomeni I. Bounartzi
Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Ioannis Niopas
Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Preferred Abstract (Original): 

Diosmetin, 3′,5,7-trihydroxy-4′-methoxyflavone, is the aglycone of the flavonoid glycoside diosmin that occurs naturally in foods of plant origin. Diosmin exhibits antioxidant and anti-inflammatory activities, improves venous tone and it is used for the treatment of chronic venous insufficiency. Diosmin is hydrolyzed by enzymes of intestinal microflora before absorption of its aglycone diosmetin. A specific, sensitive, precise, accurate and robust HPLC assay for the determination of diosmetin in human plasma was developed and validated. Diosmetin and the internal standard 7-ethoxycoumarin were isolated from plasma by liquid–liquid extraction and separated on a C8reversed-phase column with methanol–water–acetic acid (55:43:2, v/v/v) as the mobile phase at 43°C. Peaks were monitored at 344 nm. The method was linear in the 10–300 ng/mL concentration range (r > 0.999). Recovery for diosmetin and internal standard was greater than 89.7 and 86.8%, respectively. Intra-day and inter-day precision for diosmetin ranged from 1.6 to 4.6 and from 2.2 to 5.3%, respectively, and accuracy was better than 97.9%. Copyright © 2004 John Wiley & Sons, Ltd.

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