Home › nidaljaradat › Publications › Published Researches

Synthesis and Biological Activities of a Novel Naringin Based Heterocyclic Derivatives

nidaljaradat's picture
Mon, 2016-02-01 10:54 — Nidal Amin Jaradat
Journal Title, Volume, Page: 
Jodeh & al. / Mor. J. Chem. 3 N°X (2015) 242-250
Year of Publication: 
2016
Authors: 
Shehdeh Jodeh
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Nuha Abdel Rahman Shawarb
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Nidal Amin Jaradat
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
[email protected]
Ismail Warad
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Fatima Mohammed Hussen
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Motasem Almasri
Department of Biology, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Rachid Salghi
Laboratory of Applied Chemistry and Environment , ENSA, Ibn Zohr University, PO Box 1136, 80000 Agadir, Morocco
Preferred Abstract (Original): 
A number of  naringin based heterocyclic derivatives dioxolan e and  imidazolidin e have been synthesized and  evaluated for their  antioxidant and  biological activi ties. The chemical structures of the newly synthesized  compounds were verified on the basis of spectral  and elemental methods of analysi s. Investigation of  antibacterial  activity of the se compounds w as determined by measuring  MIC value using  broth micro d ilution method for G ram - positive and Gram - negative bacteria , among th e various synthesized compounds. D ioxolane  showed the highest antibacterial activity with  minimal inhibitory concentration (MIC) of 0. 125 mg/ml ,  in  addition this compound exhibit the best antioxidant activity with inhibition concentration ( IC 50 ) of 18.7 μg/mL , compared with other semi synthetic derivative .