Naringin | An-Najah Staff

Synthesis and Biological Activities of a Novel Naringin Based Heterocyclic Derivatives

Mon, 2016-02-01 10:54 — Nidal Amin Jaradat

Journal Title, Volume, Page:

Jodeh & al. / Mor. J. Chem. 3 N°X (2015) 242-250

Year of Publication:

2016

Authors:

Shehdeh Jodeh

Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine

Nuha Abdel Rahman Shawarb

Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine

Nidal Amin Jaradat

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

Current Affiliation:

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

[email protected]

Ismail Warad

Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine

Fatima Mohammed Hussen

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

Motasem Almasri

Department of Biology, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine

Rachid Salghi

Laboratory of Applied Chemistry and Environment , ENSA, Ibn Zohr University, PO Box 1136, 80000 Agadir, Morocco

Preferred Abstract (Original):

A number of naringin based heterocyclic derivatives dioxolan e and imidazolidin e have been synthesized and evaluated for their antioxidant and biological activi ties. The chemical structures of the newly synthesized compounds were verified on the basis of spectral and elemental methods of analysi s. Investigation of antibacterial activity of the se compounds w as determined by measuring MIC value using broth micro d ilution method for G ram - positive and Gram - negative bacteria , among th e various synthesized compounds. D ioxolane showed the highest antibacterial activity with minimal inhibitory concentration (MIC) of 0. 125 mg/ml , in addition this compound exhibit the best antioxidant activity with inhibition concentration ( IC 50 ) of 18.7 μg/mL , compared with other semi synthetic derivative .

Synthesis and Biological Activities of a Novel Naringin based Heterocyclic Derivatives

Thu, 2016-01-28 12:46 — Ismail Warad

Journal Title, Volume, Page:

Moroccan Journal of Chemistry, 3(1) 242-250

Year of Publication:

2016

Link:

http://revues.imist.ma/?journal=morjchem&page=article&op=view&path[]=4254

Authors:

Shehdeh Jodeh

Corresponding author, E-mail: [email protected] (S. Jodeh) Received 26 Dec 2015, Revised 11 Jan 2016, Accepted 20 Jan 2016

Current Affiliation:

Department of Chemistry, An-Najah National University, Nablus, Palestine

[email protected]

Nuha Shawarb

Current Affiliation:

Department of Chemistry, An-Najah National University, Nablus, Palestine.

N.Jaradat

Current Affiliation:

College of Pharmacy, An-Najah National University, Nablus, Palestine

I.Warad

Current Affiliation:

Department of Chemistry, An-Najah National University, Nablus, Palestine.

[email protected]

F.Hussein

Current Affiliation:

College of Pharmacy, An-Najah National University, Nablus, Palestine

M.El-Masri

Current Affiliation:

Department of Biochemistry, Genetics Laboratory An-Najah National University, Nablus, Palestine

R.Salghi

Current Affiliation:

Laboratory of Applied Chemistry and Environment, ENSA, Ibn Zohr University, PO Box 1136, 80000 Agadir, Morocco

Preferred Abstract (Original):

A number of naringin based heterocyclic derivatives dioxolane and imidazolidine have been synthesized and evaluated for their antioxidant and biological activities. The chemical structures of the newly synthesized compounds were verified on the basis of spectral and elemental methods of analysis. Investigation of antibacterial activity of these compounds was determined by measuring MIC value using broth micro dilution method for Gram-positive and Gram-negative bacteria, among the various synthesized compounds. Dioxolane showed the highest antibacterial activity with minimal inhibitory concentration (MIC) of 0.125mg/ml, in addition this compound exhibit the best antioxidant activity with inhibition concentration (IC50) of 18.7 μg/mL, compared with other semi synthetic derivative

Dissolution Enhancement of Flavonoids by Solid Dispersion in PVP and PEG Matrixes: A Comparative Study

Mon, 2013-12-30 14:18 — Feras I. Qanaze

Journal Title, Volume, Page:

Journal of Applied Polymer Science, Vol. 102, 460 – 471

Year of Publication:

2006

Link:

http://onlinelibrary.wiley.com/doi/10.1002/app.24200/abstract

Authors:

F. I. Kanaze

Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

Current Affiliation:

Department of Pharmacy,Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine

[email protected]

E. Kokkalou

I. Niopas

Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

M. Georgarakis

Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

A. Stergiou

Applied Physics Laboratory, Department of Physics, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece

D. Bikiaris

Laboratory of Organic Chemical Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece

Preferred Abstract (Original):

Polyvinylpyrrolidone (PVP) and poly(ethylene glycol) (PEG) solid dispersion systems with flavanone glycosides, naringin and hesperidin, and their aglycones, naringenin and hesperetin, were prepared, using solvent evaporation method, to enhance their dissolution rates that may affect their bioavailability. Drug release of both flavanone glycosides and their aglycones was directly affected by the physical state of solid dispersions. Powder-XRD technique in combination with scanning and transmission electron microscopy revealed that PVP polymer formed amorphous nanodispersion systems with flavanone aglycones, while such systems could not be formed with their glycosides, which are bulkier molecules. Fourier transform infrared spectra suggest the presence of hydrogen bonds between PVP carbonyl groups and hydroxyl groups of both flavanone aglycones. These interactions prevent the crystallization of naringenin and hesperetin aglycones in PVP matrix. On the other hand, the ability of PEG carrier to form hydrogen bonds with flavanone glycosides or aglycones was limited, and as a result both flavanone glycosides and their aglycones remain in the crystalline form. For this reason, the solubility enhancement of PEG solid dispersions was lower than when PVP was used as drug carrier. At pH 6.8, the % release of naringenin and hesperetin from PVP/naringenin–hesperetin (80/20 w/w) solid dispersion was 100% while in PEG solid dispersions, it was not higher than 60–70%. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 102: 460–471, 2006

Simultaneous Reversed-Phase High-Performance Liquid Chromatographic Method for the ‎Determination of Diosmin, Hesperidin and Naringin in Different Citrus Fruit Juices and ‎Pharmaceutical Formulations

Thu, 2013-12-26 13:41 — Feras I. Qanaze

Journal Title, Volume, Page:

Volume 33, Issue 2, Pages 243–249

Year of Publication:

2003

Link:

http://www.sciencedirect.com/science/article/pii/S0731708503002899

Authors:

Feras Imad Kanaze

Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

Current Affiliation:

Department of Pharmacy,Faculty of Medicine & Health Sciences, An-Najah National University, Nablus, Palestine

[email protected]

Chrysi Gabrieli

Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

Eugene Kokkalou

Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

Manolis Georgarakis

Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

Ioannis Niopas

Department of Pharmacy, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece

Preferred Abstract (Original):

Diosmin, hesperidin and naringin are flavonoid glycosides that occur naturally in citrus fruits. They exert a variety of pharmacological properties such as anti-inflammatory, antioxidant and free radical scavenging and antiulcer effects and also inhibit selected cytochrome P-450 enzymes resulting in drug interactions. A reversed-phase high-performance liquid chromatographic method has been developed for the simultaneous determination of diosmin, hesperidin and naringin in different citrus fruit juices and pharmaceutical preparations. Diosmin, hesperidin, naringin and the internal standard rhoifolin were separated using tetrahydrofuran/water/acetic acid (21:77:2, v/v/v) as the mobile phase at 34 °C, using a C8 reversed-phase column. The method was linear in the 0.25–20.0 μg/ml concentration range for all three flavonoid glycosides (r>0.999). The method has been successfully applied to the determination of all three flavonoid glycosides in several samples of different citrus fruit juices sold in Greece and for the determination of diosmin and hesperidin in pharmaceutical preparations.