Synthesis of Novel Biologically Active Mono Acid Esters Derived From The Constituents of Urtica Pilulifera

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Journal Title, Volume, Page: 
Iranian journal of pharmaceutical research (IJPR) 01/2013; DOI:ID: 5287-IJPR
Year of Publication: 
2014
Authors: 
Ahmad Husein
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Waheed Jondi
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Mohammed Ali-Shtayeh
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Nidal A. Zatar
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

New mono acid esters have been synthesized from the reaction of benzoic acid and mono-hydroxybenzoic acids with 2-phenoxyethanol separated from Urtica pilulifera, characterized, and screened for possible antioxidant, antifungal, antimicrobial and anticancer activities. 2-phenoxyethyl 4-hydroxy benzoate showed considerable activity against MCF-7 with IC50 is less than 62.5 µg/ml, and complete inhibition at a concentration less than 37.5 µg/ml against M. canis and less than 50 µg/ml against T. rubrum. On the other hand 2-phenoxyethyl 2-hydroxy benzoate reveals 70% of gentamicin against K. pneumoniae.

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