dioxolan | An-Najah Staff

Synthesis and Biological Activities of a Novel Naringin Based Heterocyclic Derivatives

Mon, 2016-02-01 10:54 — Nidal Amin Jaradat

Journal Title, Volume, Page:

Jodeh & al. / Mor. J. Chem. 3 N°X (2015) 242-250

Year of Publication:

2016

Authors:

Shehdeh Jodeh

Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine

Nuha Abdel Rahman Shawarb

Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine

Nidal Amin Jaradat

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

Current Affiliation:

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

[email protected]

Ismail Warad

Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine

Fatima Mohammed Hussen

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

Motasem Almasri

Department of Biology, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine

Rachid Salghi

Laboratory of Applied Chemistry and Environment , ENSA, Ibn Zohr University, PO Box 1136, 80000 Agadir, Morocco

Preferred Abstract (Original):

A number of naringin based heterocyclic derivatives dioxolan e and imidazolidin e have been synthesized and evaluated for their antioxidant and biological activi ties. The chemical structures of the newly synthesized compounds were verified on the basis of spectral and elemental methods of analysi s. Investigation of antibacterial activity of the se compounds w as determined by measuring MIC value using broth micro d ilution method for G ram - positive and Gram - negative bacteria , among th e various synthesized compounds. D ioxolane showed the highest antibacterial activity with minimal inhibitory concentration (MIC) of 0. 125 mg/ml , in addition this compound exhibit the best antioxidant activity with inhibition concentration ( IC 50 ) of 18.7 μg/mL , compared with other semi synthetic derivative .

Synthesis and Biological Activities of a Novel Naringin based Heterocyclic Derivatives

Thu, 2016-01-28 12:46 — Ismail Warad

Journal Title, Volume, Page:

Moroccan Journal of Chemistry, 3(1) 242-250

Year of Publication:

2016

Link:

http://revues.imist.ma/?journal=morjchem&page=article&op=view&path[]=4254

Authors:

Shehdeh Jodeh

Corresponding author, E-mail: [email protected] (S. Jodeh) Received 26 Dec 2015, Revised 11 Jan 2016, Accepted 20 Jan 2016

Current Affiliation:

Department of Chemistry, An-Najah National University, Nablus, Palestine

[email protected]

Nuha Shawarb

Current Affiliation:

Department of Chemistry, An-Najah National University, Nablus, Palestine.

N.Jaradat

Current Affiliation:

College of Pharmacy, An-Najah National University, Nablus, Palestine

I.Warad

Current Affiliation:

Department of Chemistry, An-Najah National University, Nablus, Palestine.

[email protected]

F.Hussein

Current Affiliation:

College of Pharmacy, An-Najah National University, Nablus, Palestine

M.El-Masri

Current Affiliation:

Department of Biochemistry, Genetics Laboratory An-Najah National University, Nablus, Palestine

R.Salghi

Current Affiliation:

Laboratory of Applied Chemistry and Environment, ENSA, Ibn Zohr University, PO Box 1136, 80000 Agadir, Morocco

Preferred Abstract (Original):

A number of naringin based heterocyclic derivatives dioxolane and imidazolidine have been synthesized and evaluated for their antioxidant and biological activities. The chemical structures of the newly synthesized compounds were verified on the basis of spectral and elemental methods of analysis. Investigation of antibacterial activity of these compounds was determined by measuring MIC value using broth micro dilution method for Gram-positive and Gram-negative bacteria, among the various synthesized compounds. Dioxolane showed the highest antibacterial activity with minimal inhibitory concentration (MIC) of 0.125mg/ml, in addition this compound exhibit the best antioxidant activity with inhibition concentration (IC50) of 18.7 μg/mL, compared with other semi synthetic derivative