Antibacterial activity

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Synthesis and Biological Activities of a Novel Naringin Based Heterocyclic Derivatives

Journal Title, Volume, Page: 
Jodeh & al. / Mor. J. Chem. 3 N°X (2015) 242-250
Year of Publication: 
2016
Authors: 
Shehdeh Jodeh
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Nuha Abdel Rahman Shawarb
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Nidal Amin Jaradat
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Ismail Warad
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Fatima Mohammed Hussen
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Motasem Almasri
Department of Biology, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Rachid Salghi
Laboratory of Applied Chemistry and Environment , ENSA, Ibn Zohr University, PO Box 1136, 80000 Agadir, Morocco
Preferred Abstract (Original): 
A number of  naringin based heterocyclic derivatives dioxolan e and  imidazolidin e have been synthesized and  evaluated for their  antioxidant and  biological activi ties. The chemical structures of the newly synthesized  compounds were verified on the basis of spectral  and elemental methods of analysi s. Investigation of  antibacterial  activity of the se compounds w as determined by measuring  MIC value using  broth micro d ilution method for G ram - positive and Gram - negative bacteria , among th e various synthesized compounds. D ioxolane  showed the highest antibacterial activity with  minimal inhibitory concentration (MIC) of 0. 125 mg/ml ,  in  addition this compound exhibit the best antioxidant activity with inhibition concentration ( IC 50 ) of 18.7 μg/mL , compared with other semi synthetic derivative .
warad's picture

Synthesis and Biological Activities of a Novel Naringin based Heterocyclic Derivatives

Journal Title, Volume, Page: 
Moroccan Journal of Chemistry, 3(1) 242-250
Year of Publication: 
2016
Authors: 
Shehdeh Jodeh
Corresponding author, E-mail: [email protected] (S. Jodeh) Received 26 Dec 2015, Revised 11 Jan 2016, Accepted 20 Jan 2016
Current Affiliation: 
Department of Chemistry, An-Najah National University, Nablus, Palestine
Nuha Shawarb
Current Affiliation: 
Department of Chemistry, An-Najah National University, Nablus, Palestine.
N.Jaradat
Current Affiliation: 
College of Pharmacy, An-Najah National University, Nablus, Palestine
I.Warad
Current Affiliation: 
Department of Chemistry, An-Najah National University, Nablus, Palestine.
F.Hussein
Current Affiliation: 
College of Pharmacy, An-Najah National University, Nablus, Palestine
M.El-Masri
Current Affiliation: 
Department of Biochemistry, Genetics Laboratory An-Najah National University, Nablus, Palestine
R.Salghi
Current Affiliation: 
Laboratory of Applied Chemistry and Environment, ENSA, Ibn Zohr University, PO Box 1136, 80000 Agadir, Morocco
Preferred Abstract (Original): 
A number of naringin based heterocyclic derivatives dioxolane and  imidazolidine have been synthesized and evaluated for their antioxidant and biological activities. The chemical structures of the newly synthesized compounds were verified on the basis of spectral and elemental methods of analysis. Investigation of antibacterial activity of these compounds was determined by measuring  MIC value using broth micro dilution method for Gram-positive and Gram-negative bacteria, among the various synthesized compounds. Dioxolane showed the highest antibacterial activity with minimal inhibitory concentration (MIC) of 0.125mg/ml, in addition  this compound exhibit the best antioxidant activity with inhibition concentration (IC50) of 18.7 μg/mL, compared with other semi synthetic derivative
MSShtayeh's picture

Antimicrobial Activities of Six Plants Used in Traditional Arabic Palestinian Herbal Medicine

Journal Title, Volume, Page: 
African journal of microbiology research 01/2014
Year of Publication: 
2014
Authors: 
Husein A I
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Ali-Shtayeh M S
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Jamous R M
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Abu Zaitoun S Y
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Waheed Jondi
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Zatar NA-A
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Ethanolic extracts of six plants: Arum palaestinum Bioss, Urtica pilulifera L., Thymbra capitata (L.) Cav., Origanum syriacum L., Teucrium creticum L., and Teucrium polium L., used in Traditional Arabic Palestinian Herbal Medicine were evaluated for their antibacterial, anti-candida, and antidermatophyte activities using well diffusion, micro-dilution and food poisoned techniques. The extracts were tested against: six bacterial strains including Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhi, Escherichia coli and Klebsiella pneumoniae; five Candida albicans isolates, and two dermatophytes: Microsporum canis, and Trichophyton rubrum. The most active plants extracts were T. capitata and O. syriacum against the tested bacteria, while the remaining plant extracts did not express any activity or exhibited only very low activity against tested bacteria species and candida isolates. O. syriacum was also the most active plant against all Candida strains with inhibition zones that ranged from 22.5 to 29.5 mm. On the other hand, T. capitata extract showed the highest activity against the test dermatophytes (producing a complete inhibition at = 45 µg/mL).

Nidal Zatar's picture

Antimicrobial Activities of Six Plants Used in Traditional Arabic Palestinian Herbal Medicine

Journal Title, Volume, Page: 
African journal of microbiology research 01/2014
Year of Publication: 
2014
Authors: 
Husein A I
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Ali-Shtayeh M S
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Jamous R M
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Abu Zaitoun S Y
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Waheed Jondi
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Zatar NA-A
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Ethanolic extracts of six plants: Arum palaestinum Bioss, Urtica pilulifera L., Thymbra capitata (L.) Cav., Origanum syriacum L., Teucrium creticum L., and Teucrium polium L., used in Traditional Arabic Palestinian Herbal Medicine were evaluated for their antibacterial, anti-candida, and antidermatophyte activities using well diffusion, micro-dilution and food poisoned techniques. The extracts were tested against: six bacterial strains including Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa, Salmonella typhi, Escherichia coli and Klebsiella pneumoniae; five Candida albicans isolates, and two dermatophytes: Microsporum canis, and Trichophyton rubrum. The most active plants extracts were T. capitata and O. syriacum against the tested bacteria, while the remaining plant extracts did not express any activity or exhibited only very low activity against tested bacteria species and candida isolates. O. syriacum was also the most active plant against all Candida strains with inhibition zones that ranged from 22.5 to 29.5 mm. On the other hand, T. capitata extract showed the highest activity against the test dermatophytes (producing a complete inhibition at = 45 µg/mL). 

waheedjj's picture

Antimicrobial Activities of Six Plants Used in Traditional Arabic Palestinian Herbal Medicine

Journal Title, Volume, Page: 
African journal of microbiology research 01/2014
Year of Publication: 
2014
Authors: 
Husein A I
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Ali-Shtayeh M S
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Jamous R M
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Abu Zaitoun S Y
Biodiversity and Environmental Research Center (BERC),Til Village, Nablus, Palestine
Waheed Jondi
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Zatar NA-A
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

mohammed-alnuri's picture

Antimicrobial Activity of 20 Plants Used in Folkloric ‎Medicine in the Palestinian Area

Journal Title, Volume, Page: 
Journal of Ethnopharmacology Volume 60, Issue 3, Pages 265–271
Year of Publication: 
1998
Authors: 
M.A Al-Nuri
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Y.R Faidi
Department of Medical Technology, An-Najah National University, Nablus, Palestine
M.S Ali-Shtayeh
Department of Biological Sciences, An-Najah National University, Nablus, Palestine
Reem M.-R Yaghmour
Department of Biological Sciences, An-Najah National University, Nablus, Palestine
Khalid Salem
Department of Biology, Al-Quds University, Abu Dis, Palestine
Preferred Abstract (Original): 

Ethanolic and aqueous extracts of 20 Palestinian plant species used in folk medicine were investigated for their antimicrobial activities against five bacterial species (Staphylococcus aureusEscherichia coli,Klebsiella pneumoniaeProteus vulgarisPseudomonas aeruginosa) and one yeast (Candida albicans). The plants showed 90% of antimicrobial activity, with significant difference in activity between the different plants. The most antimicrobially active plants were Phagnalon rupestre and Micromeria nervosa, whereas, the least active plant was Ziziphus spina-christi. Only ten of the tested plant extracts were active against C. albicans, with the most active from M. nervosa and Inula viscosa and the least active from Ruscus aculeatus. Of all extracts the ethanolic extract of M. nervosa was the most active, whereas, the aqueous extract of Phagnalon rupestre was the most active of all aqueous extracts tested. The ethanolic extracts (70%) showed activity against both Gram positive and negative bacteria and 40% of these extracts showed anticandidal activity, whereas, 50% of the aqueous extracts showed antibacterial activity and 20% of these extracts showed anticandidal activity.

1390's picture

Antibacterial Activity of Selected Palestinian Wild Plant Extracts against Multidrug-Resistant Clinical Isolate of Streptococcus Pneumoniae

Journal Title, Volume, Page: 
Journal of Pharmacy Research 10/2013; 1(10):963-969
Year of Publication: 
2013
Authors: 
Ghadeer Omar
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Saleh Fares
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Lubna Abdallah
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Current Affiliation: 
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Motasem Almasri
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Ahmad Slaileh
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Zakaria Zurba
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Zakaria Zurba
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Preferred Abstract (Original): 

Streptococcus pneumoniae is one of the most important bacterial pathogens that affect respiratory system. The occurrence of multidrug-resistant strains of S. pneumoniae necessitates the discovery of new classes of anti-pneumonia drugs. As some of the medicinal plants and their extracts have antibacterial activity, we aimed to investigate the antibacterial potential of five Palestinian wild medicinal plants including Echinops adenocaulos, Parietaria judaica, Urtica urens, Verbascum fruticulosum and Vitex agnus-castus against multidrug-resistant strain of S. pneumoniae, which was screened for its antibiotic resistance profile showing 67% resistance of the tested antibiotics. In this research micro-broth dilution method was used to study the inhibitory activity of ethanol, distilled water and Zamzam water extracts of all plants under investigation. The obtained results showed that all Zamzam extracts of the five studied plant species inhibited the growth of S. pneumoniae. It was clearly noticed that there was a difference in the antibacterial activity between distilled water and Zamzam water extracts recording higher activity in the Zamzam water extract of some of the studied plant species. Verbascum fruticulosum distilled water extract was the most effective one with MIC equal to 0.195 mg/ml. In general, both water extracts were more bioactive than the ethanol extracts for all the examined plants. These results confirmed the possibility of using these plant species in medicine and pharmaceutical industry of new drugs for the treatment of multidrug-resistant clinical isolates of S. pneumoniae.

Ghader Omar's picture

Antibacterial Activity of Selected Palestinian Wild Plant Extracts against Multidrug-Resistant Clinical Isolate Of Streptococcus Pneumoniae

Journal Title, Volume, Page: 
Journal of Pharmacy Research 10/2013; 1(10):963-969
Year of Publication: 
2013
Authors: 
Ghadeer Omar
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Current Affiliation: 
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Saleh Fares
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Lubna Abdallah
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Motasem Almasri
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Ahmad Slaileh
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Zakaria Zurba
Department of Biology & Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine.
Preferred Abstract (Original): 

Streptococcus pneumoniae is one of the most important bacterial pathogens that affect respiratory system. The occurrence of multidrug-resistant strains of S. pneumoniae necessitates the discovery of new classes of anti-pneumonia drugs. As some of the medicinal plants and their extracts have antibacterial activity, we aimed to investigate the antibacterial potential of five Palestinian wild medicinal plants including Echinops adenocaulos, Parietaria judaica, Urtica urens, Verbascum fruticulosum and Vitex agnus-castus against multidrug-resistant strain of S. pneumoniae, which was screened for its antibiotic resistance profile showing 67% resistance of the tested antibiotics. In this research micro-broth dilution method was used to study the inhibitory activity of ethanol, distilled water and Zamzam water extracts of all plants under investigation. The obtained results showed that all Zamzam extracts of the five studied plant species inhibited the growth of S. pneumoniae. It was clearly noticed that there was a difference in the antibacterial activity between distilled water and Zamzam water extracts recording higher activity in the Zamzam water extract of some of the studied plant species. Verbascum fruticulosum distilled water extract was the most effective one with MIC equal to 0.195 mg/ml. In general, both water extracts were more bioactive than the ethanol extracts for all the examined plants. These results confirmed the possibility of using these plant species in medicine and pharmaceutical industry of new drugs for the treatment of multidrug-resistant clinical isolates of S. pneumoniae.

adwank's picture

Antibacterial Activity of Rhus Coriaria. L Extracts Growing in Palestine

Journal Title, Volume, Page: 
Journal of Islamic Studies 01/2005; 13(2):147-153
Year of Publication: 
2005
Authors: 
Bassam Abu-Shanab
Department of Veterinary Medicine, Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Nablus, Palestine
Ghaleb Adwan
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Dauod Abu-Safiya
Faculty of Agriculture and Veterinary Medicine, An-Najah National University, Nablus, Palestine
Kamel Adwan
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Moad Abu-Shanab
Department of Pharmacy, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Disk diffusion and micro-dilution techniques were used to determine the antibacterial activity of water, ethanolic and methanolic extracts of Rhus coriaria ripe berries against five clinical bacterial strains (Methicillin-resistant Staphylococcus aureus (MRSA), multi-drug resistant Pseudomonas aeruginosa, enterohemorrhagic Escherichia coli O157 (EHEC), Proteus vulgaris and Klebsiella pneumoniae). Bacillus subtilis ATCC6633 was used as a reference strain. The zone of inhibition varies depending on bacterial species and type of extract. The average diameter of inhibition zones ranges from 0 to 19 mm, 15 to 25 mm and 15 to 22 mm for water, ethanolic and methanolic extract, respectively. The MIC value of ethanolic extract was 1.25 mg/ml against MRSA, EHEC, P. aeruginosa and Proteus vulgaris, while 0.156 mg/ml against B. subtilis. In general these results showed that the antibacterial activity of R. coriaria ripe berries extracts was more effective against Gram-positive bacteria than Gram-negative.

adwank's picture

Antibacterial Activity of Rosmarinus Officinalis L. Alone and In Combination with Cefuroxime against Methicillin–Resistant Staphylococcus Aureus

Journal Title, Volume, Page: 
Asian Pacific Journal of Tropical Medicine Volume 3, Issue 2, February 2010, Pages 121–123
Year of Publication: 
2010
Authors: 
Naser Jarrar
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Awni Abu-Hijleh
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Kamel Adwan
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Objective To determine the antimicrobial activity of rosemary (Rosmarinus officinalis L.) and to investigate the synergistic effects of this extract combined with ceforuxime against methicillin-resistant Staphylococcus aureus (MRSA).
Methods
The inhibitory and bactericidal activities of rosemary ethanol extract, alone and in combination with cefuroxime, were studied.
Results
The minimum inhibitory concentrations (MICs) of the ethanol extract of rosemary were in the range of 0.39–3.13 mg/mL. The minimum bactericidal concentrations (MBCs) were usually equal to or double that MICs. The antimicrobial activity of combinations of the ethanol extract of rosemary and cefuroxime indicated their synergistic effects against all MRSAs.
Conclusions The present work clearly demonstrates that rosemary has a key role in the elevation of susceptibility to β-lactams. 

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