An-Najah Staff

Objective: To evaluate the possible in vitro interaction between ethanolic extracts of Rhus coriaria (R. coriaria) (seed), Sacropoterium spinosum (S. spinosum) (seed), Rosa damascena (R.damascene) (flower) and certain known antimicrobial drugs including oxytetracycline HCl,pweansi ccialrlirnie Gd ,o cuetp ahgaaleinxsint ,3 s ucllfiandicimale sthtroaxiinnse oafs msoudltiiudmru, ga-nrde seinstraonflto xPasceiund. oTmhoisn assy naeerrguyg sintuodsay (P. aeruginosa).
Methods: Evaluation of synergy interaction between plant extracts and antimicrobial agents was carried out using microdilution method.
Results: The results of this satnudd yte ssht oawnetdim thicarto tbhiearle a igse an tdse. cTrehaes em ions tt hien tMerIeCs tiinn gc arsees uolft cwomasb tihnaatt iothne o cf oemthbainnoaltiico np labnett wexeterna cRts.coriaria and these antibiotics, showed a high decrease in minimum inhibitory concentration (MIC),and a strong bactericidal activity against these strains.
Conclusions: These results may indicate that combinations between R. coriaria extract and these antibiotics could be useful in fighting emerging drug-resistance P. aeruginosa, which may due to that R. coriaria extract contain natural iunnhdiebriwtoarys wleoardkiinngg tboy t hdeif fiedreenntti fmiceacthioann iosfm tsh eo ra icnthivieb imtinogle ecfuflluesx ppruemsepnst. Nino wR . wceo rhiaarviea .e xFpuerrthimere,n itns vivo experiments are needed to confirm pseudomonal protection.

Objectives: This study has been done to evaluate the interaction between ethanolic extracts of Rhus coriaria (seed), Psidium guajava (Leaf), Lawsonia inermis (Leaf) and Sacropoterium spinosum (seed) and antimicrobial drugs including oxytetracycline HCl, enrofloxacin, gentamicin sulphate and sulfadimethoxine against four clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).
Methodology: Evaluation of the interaction between ethanolic extracts and different antimicrobial agents has been done using well-diffusion method.
Results: It showed that ethanolic extracts increase the inhibition zones of oxytetracycline HCl, gentamicin sulphate, and sulfadimethoxine, while combinations between these plant extracts and enrofloxacin decrease inhibition zone.
Conclusion: This study probably suggests the possibility of concurrent use of these antimicrobial drugs and plant extracts in combination in treating infections caused by S. aureus strains or at least the concomitant administration may not impair the antimicrobial activity of these antibiotics.