Differential-pulse polarography

Electrochemical Study on the Determination of Tinidazole in Tablets

Mon, 2014-07-07 11:01 — Raqi Mohammad Hasan Shubietah

Journal Title, Volume, Page:

Journal of Pharmaceutical and Biomedical Analysis Volume 21, Issue 4, Pages 881–886

Year of Publication:

1999

Link:

http://www.sciencedirect.com/science/article/pii/S0731708599002010

Authors:

Raqi M. Shubietah

Faculty of Pharmacy, An-Najah National University, Nablus, P.O. Box 707, Palestine

Current Affiliation:

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

[email protected]

Ali Z. Abu Zuhri

Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Suleiman Al-Khalil

Medical Technology Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Ibrahim El-Hroub

Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Preferred Abstract (Original):

The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8-11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongly acidic solution (pH < 4.5), one reduction peak was obtained and it was suitable for analytical purposes. A method for the determination of tinidazole by DP polarography in Britton-Robinson buffer of pH 3.0, which allows quantification over the range 0.03-7.30 microg/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mean recovery and relative standard deviation of 98.7 and 3%, respectively. Excipients did not interfere in the determination.

Spectrophotometric and Polarographic Studies of Di-2-Pyridyl Ketone 2-‎ Thienoylhydrazone

Tue, 2014-04-01 08:19 — Mohammed Abdullah Al-Nuri

Journal Title, Volume, Page:

Analytical Letters Volume 27, Issue 10

Year of Publication:

1994

Link:

http://www.tandfonline.com/doi/abs/10.1080/00032719408002640#.UzpbrvmSwgY

Authors:

Mohamad Al-Nuri

Chemistry Department, An-Najah National University, Nablus, Palestine

Current Affiliation:

Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine

[email protected]

Mohamed Hannoun

Chemistry Department, An-Najah National University, Nablus, Palestine

Ali Z. Abu Zuhri

Department of Chemistry, Faculty of Science, UAE , University, Al-Ain , P.O.Box 17551, United Arab Emirates

Mohamad S. El-Shahawi

Department of Chemistry, Faculty of Science, UAE , University, Al-Ain , P.O.Box 17551, United Arab Emirates

Mostafa M. Kamal

Department of Chemistry, Faculty of Science, UAE , University, Al-Ain , P.O.Box 17551, United Arab Emirates

Preferred Abstract (Original):

The spectral and differential pulse polarographic (DPP) behaviour of di-2-pyridyl ketone 2-thienoylhydrazone (DPKTH) has been investigated in 30% (v/v) ethanol-buffer mixtures over a wide range of pH (2.0-12.0). The spectral bands located at 325, 276, 230 and 208 nm of the DPKTH in ethanol are assigned to the possible electronic transitions of the molecule. The spectral data at various pH values indicates that the molecule characterized by the keto = enol tautomerization and the pK_a value for the enolic form of the compound is determined in aqueous ethanol and was found to be 10.6. The effect of various operational parameters on the reduction current and the mechanism of the electrode reaction of DPKTH at the DME are discussed. The main reduction peaks are attributed to the reduction of C=N centre of both the keto and enol forms. This behaviour is compared with the DPP behaviour of the other related acid hydrazone compounds. The applicability of DPP technique for the trace determination of DPKTH was tested under the optimum experimental conditions and the detection limit is found to be 0.09 μm.

Electrochemical Study on the Determination of Tinidazole in Tablets

Wed, 2013-09-04 08:33 — Suleiman Ibrahim Al-khalil

Journal Title, Volume, Page:

Journal of Pharmaceutical and Biomedical Analysis Volume 21, Issue 4, December 1999, Pages 881–886

Year of Publication:

1999

Link:

http://www.sciencedirect.com/science/article/pii/S0731708599002010

Authors:

Ali Z. Abu Zuhri

Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

[email protected]

Suleiman Al-Khalil

Medical Technology Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Current Affiliation:

Department of Medical Laboratory Sciences, Faculty of Science, An-Najah National University, Palestine

[email protected]

Raqi M. Shubietah

Faculty of Pharmacy, An-Najah National University, Nablus, P.O. Box 707, Palestine

Ibrahim El-Hroub

Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Preferred Abstract (Original):

The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8–11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongly acidic solution (pH<4.5), one reduction peak was obtained and it was suitable for analytical purposes. A method for the determination of tinidazole by DP polarography in Britton–Robinson buffer of pH 3.0, which allows quantification over the range 0.03–7.30 μg/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mean recovery and relative standard deviation of 98.7 and 3%, respectively. Excipients did not interfere in the determination.

An-Najah Staff