Electrochemical Study on the Determination of Tinidazole in Tablets

Journal Title, Volume, Page:

Journal of Pharmaceutical and Biomedical Analysis Volume 21, Issue 4, December 1999, Pages 881–886

Year of Publication:

1999

Link:

http://www.sciencedirect.com/science/article/pii/S0731708599002010

Authors:

Ali Z. Abu Zuhri

Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

[email protected]

Suleiman Al-Khalil

Medical Technology Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Current Affiliation:

Department of Medical Laboratory Sciences, Faculty of Science, An-Najah National University, Palestine

[email protected]

Raqi M. Shubietah

Faculty of Pharmacy, An-Najah National University, Nablus, P.O. Box 707, Palestine

Ibrahim El-Hroub

Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Preferred Abstract (Original):

The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8–11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongly acidic solution (pH<4.5), one reduction peak was obtained and it was suitable for analytical purposes. A method for the determination of tinidazole by DP polarography in Britton–Robinson buffer of pH 3.0, which allows quantification over the range 0.03–7.30 μg/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mean recovery and relative standard deviation of 98.7 and 3%, respectively. Excipients did not interfere in the determination.

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Electrochemical Study on the Determination of Tinidazole in Tablets