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Electrochemical Study on the Determination of Tinidazole in Tablets

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Mon, 2014-07-07 11:01 — Raqi Mohammad Hasan Shubietah
Journal Title, Volume, Page: 
Journal of Pharmaceutical and Biomedical Analysis Volume 21, Issue 4, Pages 881–886
Year of Publication: 
1999
Link: 
http://www.sciencedirect.com/science/article/pii/S0731708599002010
Authors: 
Raqi M. Shubietah
Faculty of Pharmacy, An-Najah National University, Nablus, P.O. Box 707, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
[email protected]
Ali Z. Abu Zuhri
Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine
Suleiman Al-Khalil
Medical Technology Department, An-Najah National University, Nablus, P.O. Box 707, Palestine
Ibrahim El-Hroub
Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine
Preferred Abstract (Original): 

The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8-11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongly acidic solution (pH < 4.5), one reduction peak was obtained and it was suitable for analytical purposes. A method for the determination of tinidazole by DP polarography in Britton-Robinson buffer of pH 3.0, which allows quantification over the range 0.03-7.30 microg/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mean recovery and relative standard deviation of 98.7 and 3%, respectively. Excipients did not interfere in the determination.