Pharmaceutical formulations

Electrochemical Study on the Determination of Tinidazole in Tablets

Mon, 2014-07-07 11:01 — Raqi Mohammad Hasan Shubietah

Journal Title, Volume, Page:

Journal of Pharmaceutical and Biomedical Analysis Volume 21, Issue 4, Pages 881–886

Year of Publication:

1999

Link:

http://www.sciencedirect.com/science/article/pii/S0731708599002010

Authors:

Raqi M. Shubietah

Faculty of Pharmacy, An-Najah National University, Nablus, P.O. Box 707, Palestine

Current Affiliation:

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

[email protected]

Ali Z. Abu Zuhri

Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Suleiman Al-Khalil

Medical Technology Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Ibrahim El-Hroub

Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Preferred Abstract (Original):

The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8-11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongly acidic solution (pH < 4.5), one reduction peak was obtained and it was suitable for analytical purposes. A method for the determination of tinidazole by DP polarography in Britton-Robinson buffer of pH 3.0, which allows quantification over the range 0.03-7.30 microg/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mean recovery and relative standard deviation of 98.7 and 3%, respectively. Excipients did not interfere in the determination.

Polarographic assay of Ranitidine Drugs in Pharmaceutical Formulations Polarographic assay of Ranitidine Drugs in Pharmaceutical Formulations

Wed, 2013-09-04 11:48 — Suleiman Ibrahim Al-khalil

Journal Title, Volume, Page:

Analytical Letters Volume 21, Issue 10, 1988

Year of Publication:

1988

Link:

http://www.tandfonline.com/doi/abs/10.1080/00032718808066351#preview

Authors:

Ali Z. Abu Zuhri

Chemistry Department, An-Najah National University, Nablus, West Bank

Mohammad Hannoun

Chemistry Department, An-Najah National University, Nablus, West Bank

Suleiman I. Alkhalil

Medical Laboratory Sciences Department, Faculty of Science, An-Najah National University, Nablus, West Bank

Current Affiliation:

Department of Medical Laboratory Sciences, Faculty of Science, An-Najah National University, Palestine

[email protected]

Hind Hasna

Medical Laboratory Sciences Department, Faculty of Science, An-Najah National University, Nablus, West Bank

Preferred Abstract (Original):

A simple, accurate and rapid method for the quantitative determination of five ranitidine drugs in pharmaceutical formulations (Tablets and Ampoules) is proposed. The supporting electrolyte was acetic acid-sodium acetate buffer solution (pH 5.2). An excellent linear relationship was obtained between the concentration and current with correlation coefficient 0.9996. Good agreement was obtained between the results with the d.c. polarograhic method and those by the manufacturer's method of assay.

Electrochemical Study on the Determination of Tinidazole in Tablets

Wed, 2013-09-04 08:33 — Suleiman Ibrahim Al-khalil

Journal Title, Volume, Page:

Journal of Pharmaceutical and Biomedical Analysis Volume 21, Issue 4, December 1999, Pages 881–886

Year of Publication:

1999

Link:

http://www.sciencedirect.com/science/article/pii/S0731708599002010

Authors:

Ali Z. Abu Zuhri

Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

[email protected]

Suleiman Al-Khalil

Medical Technology Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Current Affiliation:

Department of Medical Laboratory Sciences, Faculty of Science, An-Najah National University, Palestine

[email protected]

Raqi M. Shubietah

Faculty of Pharmacy, An-Najah National University, Nablus, P.O. Box 707, Palestine

Ibrahim El-Hroub

Chemistry Department, An-Najah National University, Nablus, P.O. Box 707, Palestine

Preferred Abstract (Original):

The electrochemical reduction of tinidazole has been carried out in aqueous solution in the pH range 1.8–11.3 by differential-pulse (DP) polarography. Tinidazole exhibits one or two reduction peaks depending on pH. In strongly acidic solution (pH<4.5), one reduction peak was obtained and it was suitable for analytical purposes. A method for the determination of tinidazole by DP polarography in Britton–Robinson buffer of pH 3.0, which allows quantification over the range 0.03–7.30 μg/ml, was proposed. The method was successfully applied to the determination of tinidazole in tablets with mean recovery and relative standard deviation of 98.7 and 3%, respectively. Excipients did not interfere in the determination.

An-Najah Staff