Varthemia iphionoides | An-Najah Staff

Antibacterial Activity of Common Varthemia, Varthemia Iphionoides Ethanol Extract Alone And In Combination With Cefotaxime

Sun, 2013-04-14 15:51 — Awni A. M. Abu-Hijleh

Journal Title, Volume, Page:

Advances in Biological Research 3 (5-6): 144-147

Year of Publication:

2009

Link:

http://www.idosi.org/abr/abr3%285-6%29.htm

Authors:

Awni Abu-Hijleh

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Current Affiliation:

Department of Biology, Faculty of Science, An-Najah National University, Nablus. Palestine

[email protected]

Naser Jarrar

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Kamel Adwan

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Preferred Abstract (Original):

To assess the clinical utility of the crude ethanolic extract of the leaves of Varthemia iphionoides (Compositae), minimal inhibitory concentrations (MICs) were determined using agar dilution technique. Accordingly, The MICs of of this plant extract ranged from 0.0313-1 mg/ml for three clinical taphylacaccus aureus strains and ATCC strains of Bacillus subtilis and Staphylococcus epidermidis, whereas Escherichia coli studied in this report was found to exhibit higher MIC value (4 mg/ml). The effect of combinations of ethanolic extract of Varthemia iphionoides and cefotaxime was investigated by means of fractional inhibitory concentration (FIC) indices. Using the FIC indices, synergistic interactions were observed against B. subtilis (ATCC 6633) and S. ureus strains (FIC indices of 0.75-0.875); while combinations against E. coli and S. epidermidis (ATCC 25923) exhibited antagonistic interactions (FIC indices of 2.5 to 16.4). Synergy was confirmed at cefotaxime concentrations corresponding to 1/2 MIC and an ethanol extract concentrations corresponding to 1/4 MIC and lower.

Antibacterial Activity of Common Varthemia, Varthemia Iphionoitks Ethanol Extract Alone and in Combination with Cefotaxime

Mon, 2013-03-04 13:05 — Kamel Mohammed Dauod Adwan

Journal Title, Volume, Page:

Advances in Biological Research 3 (5-6): 144-147, 2009

Year of Publication:

2009

Link:

http://www.idosi.org/abr/3%285-6%29/1.pdf

Authors:

Awni Abu-Hijleh

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Naser Jarrar

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Kamel Adwan

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Current Affiliation:

Department of Biology, Faculty of Science, An-Najah National University, Nablus. Palestine

[email protected]

Preferred Abstract (Original):

To assess the clinical utility of the crude ethanolic extract of the leaves of Varthemia iphionoides (Compositae), minimal inhibitory concentrations eJ'v1Ies) were determined using agar dilution technique. Accordingly, The MICs of of this plant extract ranged from 0.0313-1 mg/ml for three clinical Staphylacaccus aureus strains and ATCC strains of Bacillus subtilis and Staphylococcus epidermidis, whereas Escherichia coli studied in this report was fOlUld to exhibit higher 1v1Ie value (4 mg/ml). The effect of combinations of ethanolic extract of Varthemia iphionoides a0nd cefotaxime was investigated by means of fractional inhibitory concentration (FIe) indices. Using the FIe indices, synergistic interactions were observed against B. subtilis (ATCC 6633) and S. aureus strains (FIC indices of 0.75-0.875); while combinations against E. cali and S. epidermidis (ATCC 25923) exhibited antagonistic interactions (FIC indices of 2.5 to 16.4). Synergy was confirmed at cefotaxime concentrations corresponding to 1/2 MIC and an ethanol extract concentrations corresponding to 1/41v1IC and lower.

Inhibitory Effect of Varthemia iphionoides Extract on the Contractility of Isolated Rabbit Ileum

Fri, 2013-03-01 11:55 — Naser Rushdi Mahmoud Jarrar

Journal Title, Volume, Page:

Journal of Pharmacy Research;Dec2011, Vol. 4 Issue 12, p4367

Year of Publication:

2011

Link:

http://connection.ebscohost.com/c/articles/74296827/inhibitory-effect-varthemia-...

Authors:

Yousef Salameh

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Monther Abdel Fattah

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Awni Abu-Hijleh

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Ghaleb Adwan

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Naser Jarrar

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Current Affiliation:

Department of Biology, Faculty of Science, An-Najah National University, Nablus. Palestine

[email protected]

Kamel Adwan

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Preferred Abstract (Original):

Varthemia iphionoides is indigenous to Palestine, where it is traditionally being used for treatment of gastrointestinal disorders. The aim of this paper was to provide pharmacological validation to this medicinal use. Water and ethanol extracts of Varthemia iphionoides were studied on isolated rabbit ileum for spasmolytic action. These extracts showed a reduction of the amplitude and the tone of spontaneous contraction in a concentration-dependent manner. Apart from that, water extract of Varthemia iphionoides drastically diminished the increase of the contraction of the ileum caused by acetylcholine (ACh) concentration of 5.5X10-6M. This indicates that Varthemia iphionoides extract probably acts at least through muscarinic receptors blockade.

Antibacterial Activity of Common Varthemia, Varthemia iphionoitks Ethanol Extract Alone and in Combination with Cefotaxime

Fri, 2013-03-01 11:22 — Naser Rushdi Mahmoud Jarrar

Journal Title, Volume, Page:

Advances in Biological Research 3 (5-6): 144-147, 2009

Year of Publication:

2009

Link:

http://www.idosi.org/abr/abr3%285-6%29.htm

Authors:

Awni Abu-Hijleh

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Naser Jarrar

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Current Affiliation:

Department of Biology, Faculty of Science, An-Najah National University, Nablus. Palestine

[email protected]

Kamel Adwan

Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine

Preferred Abstract (Original):

To assess the clinical utility of the crude ethanolic extract of the leaves of Varthemia iphionoides (Compositae), minimal inhibitory concentrations eJ'v1Ies) were determined using agar dilution technique. Accordingly, The MICs of of this plant extract ranged from 0.0313-1 mg/ml for three clinical Staphylacaccus aureus strains and ATCC strains of Bacillus subtilis and Staphylococcus epidermidis, whereas Escherichia coli studied in this report was fOlUld to exhibit higher 1v1Ie value (4 mg/ml). The effect of combinations of ethanolic extract of Varthemia iphionoides and cefotaxime was investigated by means of fractional inhibitory concentration (FIe) indices. Using the FIe indices, synergistic interactions were observed against B. subtilis (ATCC 6633) and S. aureus strains (FIC indices of 0.75-0.875); while combinations against E. cali and S. epidermidis (ATCC 25923) exhibited antagonistic interactions (FIC indices of 2.5 to 16.4). Synergy was confirmed at cefotaxime concentrations corresponding to 1/2 MIC and an ethanol extract concentrations corresponding to 1/41v1IC and lower. Key words: Varthemia iphionoides . Medicinal plants . Antibacterial activity . Herb-drug interactions . Plant extracts

Inhibitory Effect of Varthemia Iphionoides Extract on The Contractility of Isolated Rabbit Ileum

Fri, 2013-03-01 00:38 — Kamel Mohammed Dauod Adwan

Journal Title, Volume, Page:

Journal of Pharmacy Research Vol.4.Issue 12.December 2011 Yousef Salameh et al. / Journal of Pharmacy Research 2011,4(12),4367-4368

Year of Publication:

2011

Link:

http://connection.ebscohost.com/c/articles/74296827/inhibitory-effect-varthemia-...

Authors:

Salameh, Yousef

Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine

Fattah, Monther Abdel

Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine

Abu-Hijleh, Awni

Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine

Adwan, Ghaleb

Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine

Jarrar, Naser

Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine

Adwan, Kamel

Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine

Current Affiliation:

Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine

[email protected]

Preferred Abstract (Original):

Varthemia iphionoides is indigenous to Palestine, where it is traditionally being used for treatment of gastrointestinal disorders. The aim of this paper was to provide pharmacological validation to this medicinal use. Water and ethanol extracts of Varthemia iphionoides were studied on isolated rabbit ileum for spasmolytic action. These extracts showed a reduction of the amplitude and the tone of spontaneous contraction in a concentration-dependent manner. Apart from that, water extract of Varthemia iphionoides drastically diminished the increase of the contraction of the ileum caused by acetylcholine (ACh) concentration of 5.5X10-6M. This indicates that Varthemia iphionoides extract probably acts at least through muscarinic receptors blockade.