Inhibitory Effect of Varthemia Iphionoides Extract on The Contractility of Isolated Rabbit Ileum

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Journal Title, Volume, Page: 
Journal of Pharmacy Research Vol.4.Issue 12.December 2011 Yousef Salameh et al. / Journal of Pharmacy Research 2011,4(12),4367-4368
Year of Publication: 
2011
Authors: 
Salameh, Yousef
Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine
Fattah, Monther Abdel
Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine
Abu-Hijleh, Awni
Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine
Adwan, Ghaleb
Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine
Jarrar, Naser
Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine
Adwan, Kamel
Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine
Current Affiliation: 
Department of Biology , Faculty of Science, An-Najah National University, Nablus. Palestine
Preferred Abstract (Original): 
Varthemia iphionoides is indigenous to Palestine, where it is traditionally being used for treatment of gastrointestinal disorders. The aim of this paper was to provide pharmacological validation to this medicinal use. Water and ethanol extracts of Varthemia iphionoides were studied on isolated rabbit ileum for spasmolytic action. These extracts showed a reduction of the amplitude and the tone of spontaneous contraction in a concentration-dependent manner. Apart from that, water extract of Varthemia iphionoides drastically diminished the increase of the contraction of the ileum caused by acetylcholine (ACh) concentration of 5.5X10-6M. This indicates that Varthemia iphionoides extract probably acts at least through muscarinic receptors blockade.
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