Interaction

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Evaluation of Potential Drug- Herb Interactions among a Group of Palestinian Patients With Chronic Diseases

Journal Title, Volume, Page: 
The official journal of the International Society for Complementary Medicine Research (ISCMR)201515:221 DOI: 10.1186/s12906-015-0764-7
Year of Publication: 
2015
Authors: 
Rowa’ Al-Ramahi
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Nidal Jaradat
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Ruba Shalalfeh
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Sojoud Nasir
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Yazan Manasra
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Ihab Shalalfeh
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Yasmen Esam
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Background The aim of this study was to find the prevalence of potential drug-herb interactions in patients with chronic diseases and identify factors associated with these interactions if present.
Method The study was a questionnaire based cross-sectional study. It was conducted at a number of governmental primary healthcare centers which include outpatient clinics for chronic diseases between July and November 2013. Patients come to these clinics monthly or bimonthly to receive their medications for their chronic diseases free. The patients in this study were seen at these clinics and their medications were reported from the most recent prescription in their files.
Results A total of 400 patients agreed to be interviewed, 209 (52.3 %) were females. The most commonly used medications were metformin, insulin, and enalapril. Among the patients, 237 (59.3 %) were using 395 medicinal herbs. The most commonly used herbs were sage, anise and peppermint. In 51 out of the 237 cases (21.5 %) at least one potential drug-herb interaction was found. Male patients were more likely to have potential drug-herb interactions. Patients with potential drug herb interactions were older, having a higher mean number of chronic diseases and medications (P-value < 0.05). Only 133 out of 237 (56.1 %) users told their prescribers or pharmacists before using medicinal herbs.
Conclusion Use of medicinal herbs is a common practice among Palestinian patients attending primary healthcare centers. A substantial proportion failed to disclose to their doctors or pharmacists about herbal products they used, therefore, the physicians and pharmacists are recommended to ask patients about the use of medicinal herbs to avoid any possible negative outcomes. Better counseling and communication between patients and healthcare providers is recommended. 

nidaljaradat's picture

Evaluation of Potential Drug- Herb ‎Interactions Among a Group of Palestinian ‎Patients with Chronic Diseases

Authors: 
Nidal Jaradat
Rowa’ Al-Ramahi
Ruba Shalalfeh
Sojoud Nasir
Yazan Manasra
hab Shalalfeh
Yasmen Esam
Preferred Abstract (Original): 

Background

The aim of this study was to find the prevalence of potential drug-herb interactions in patients with chronic diseases and identify factors associated with these interactions if present.

Method

The study was a questionnaire based cross-sectional study. It was conducted at a number of governmental primary healthcare centers which include outpatient clinics for chronic diseases between July and November 2013. Patients come to these clinics monthly or bimonthly to receive their medications for their chronic diseases free. The patients in this study were seen at these clinics and their medications were reported from the most recent prescription in their files.

Results

A total of 400 patients agreed to be interviewed, 209 (52.3 %) were females. The most commonly used medications were metformin, insulin, and enalapril. Among the patients, 237 (59.3 %) were using 395 medicinal herbs. The most commonly used herbs were sage, anise and peppermint. In 51 out of the 237 cases (21.5 %) at least one potential drug-herb interaction was found. Male patients were more likely to have potential drug-herb interactions. Patients with potential drug herb interactions were older, having a higher mean number of chronic diseases and medications (P-value < 0.05). Only 133 out of 237 (56.1 %) users told their prescribers or pharmacists before using medicinal herbs.

Conclusion

Use of medicinal herbs is a common practice among Palestinian patients attending primary healthcare centers. A substantial proportion failed to disclose to their doctors or pharmacists about herbal products they used, therefore, the physicians and pharmacists are recommended to ask patients about the use of medicinal herbs to avoid any possible negative outcomes. Better counseling and communication between patients and healthcare providers is recommended.

2052's picture

Efficiency of Removal of Cadmium from Aqueous Solutions by Plant Leaves and the Effects of Interaction of Combinations of Leaves on Their Removal Efficiency

Journal Title, Volume, Page: 
Journal of Environmental Management Volume 87, Issue 3, May 2008, Pages 521–532
Year of Publication: 
2008
Authors: 
R. Salim
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
M. Al-Subu
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
E. Dawod
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Removal of cadmium from aqueous solutions using 20 species of plant leaves and combinations of these leaves have been studied. Several factors affecting the removal efficiency have been studied. The most efficient types of plant leaves for the removal of cadmium are those of styrax, plum, pomegranate and walnut. The interaction effect of the combined leaf samples on the efficiency of removal of cadmium has been found to be additive in combinations involving styrax plant leaves but seems to be antagonistic in all other combinations. The optimum experimental conditions for removal of cadmium have been found to be at pH 4.1, using high concentrations of naturally dried plant leaves, using ground leaves and to remove cadmium from agitated aqueous solutions. The percentage of metal removed at an initial cadmium concentration of 10 mg/l by the most efficient types of leaves have been found to be 85% for styrax leaves, 85% for plum leaves, 80% for pomegranate leaves, 78% for walnut leaves and 77% for meddler leaves. The presence of foreign ions or complexing agents has been found to reduce the efficiency of removal of cadmium by plant leaves. About 80–85% of the cadmium in charged plant leaves has been released under the influence of changing the pH of the solution, addition of competing ions and the addition of EDTA. The results of removal of cadmium by plant leaves have been found to follow the Freundlich adsorption isotherm, first-order reaction with respect to cadmium and to have intra-pore diffusion as the rate-limiting step.

miamicg's picture

Transport and interaction of arsenic, chromium, and copper in soil associated with CCA-treated wood

Journal Title, Volume, Page: 
Chemosphere, 78(8), pp: 989-995
Year of Publication: 
2010
Authors: 
Ligang Hu
Department of Chemistry & Biochemistry, Florida International University, University Park, Miami, FL 33199, United States
Cristina Diez-Rivas
Department of Chemistry & Biochemistry, Florida International University, University Park, Miami, FL 33199, United States
A. Rasem Hasan
Department of Civil, Architectural and Environmental Engineering, University of Miami, Coral Gable, FL 33124, United States
Current Affiliation: 
Department of Civil Engineering, An-Najah National University, P.O. Box 7, Nablus, Palestine.
Helena Solo-Gabriele
Department of Civil, Architectural and Environmental Engineering, University of Miami, Coral Gable, FL 33124, United States
Lynne Fieber
Division of Marine Biology and Fisheries, Rosenstiel School of Marine & Atmospheric Science, University of Miami, FL 33149, United States
Yong Cai
Department of Chemistry & Biochemistry, Florida International University, University Park, Miami, FL 33199, United States
Preferred Abstract (Original): 
Laboratory column leaching experiments were conducted to investigate the transport and interaction of As, Cr, and Cu associated with CCA-treated wood in sand with and without peat amendment. Results showed that leaching behavior of As, Cr, and Cu in these substrates were totally different. Substrate characteristics and microorganism activity posed distinct effects on the transport and transformation of these three elements. Arsenic was rapidly leached out from the columns with or without the amendment of peat, while Cr remained in all columns during the entire experimental period (215 d). Copper was leached out only in the substrate column without peat. The presence of microorganism clearly facilitated the transport of As, while it did not show obvious effects on the transport of Cr and Cu. Interactions among these three elements were observed during the processes of adsorption and transport. The adsorption of Cu on soil was enhanced with the adsorption of As, likely caused by a more negatively charged soil surface because of As adsorption. The adsorption of Cr on soil increased the adsorption of As due to the additional As binding sites induced by Cr adsorption. These results suggest that As concentrations in the soil affected by CCA-treated wood could largely exceed predictions based on soil adsorption capacity for As. The evaluation of the impact on human health associated with CCA-treated wood should take consideration of the distinct transport characteristics of three elements and their interactions in soils.
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