hydrodynamics | An-Najah Staff

Bio-Predictive Tablet Disintegration: Effect of Water Diffusivity, Fluid Flow, Food Composition and Test Conditions

Tue, 2014-11-11 14:36 — Asma Abdelaziz Salim Radwan

Journal Title, Volume, Page:

European Journal of Pharmaceutical Sciences Volume 57, 16 June 2014, Pages 273–279

Year of Publication:

2014

Link:

http://www.sciencedirect.com/science/article/pii/S0928098713003527

Authors:

Asma Radwan

Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany

Current Affiliation:

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

[email protected]

Manfred Wagner

Max Planck Institute for Polymer Research, Mainz, Germany

Gordon L. Amidon

College of Pharmacy, The University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA

Peter Langguth

Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany

Preferred Abstract (Original):

Food intake may delay tablet disintegration. Current in vitro methods have little predictive potential to account for such effects. The effect of a variety of factors on the disintegration of immediate release tablets in the gastrointestinal tract has been identified. They include viscosity of the media, precipitation of food constituents on the surface of the tablet and reduction of water diffusivity in the media as well as changes in the hydrodynamics in the surrounding media of the solid dosage form. In order to improve the predictability of food affecting the disintegration of a dosage form, tablet disintegration in various types of a liquefied meal has been studied under static vs. dynamic (agitative) conditions. Viscosity, water diffusivity, osmolality and Reynolds numbers for the different media were characterized. A quantitative model is introduced which predicts the influence of the Reynolds number in the tablet disintegration apparatus on the disintegration time. Viscosity, water diffusivity and media flow velocity are shown to be important factors affecting dosage form disintegration. The results suggest the necessity of considering these parameters when designing a predictive model for simulating the in vivo conditions. Based on these experiments and knowledge on in vivo hydrodynamics in the GI tract, it is concluded that the disintegration tester under current pharmacopoeial conditions is operated in an unphysiological mode and no bioprediction may be derived. Recommendations regarding alternative mode of operation are made.

Hydrodynamics and Mass Transfer of Textile Vibrating-Valve Trays

Sun, 2014-05-11 13:34 — Husni Mustafa Mohammed Odeh

Journal Title, Volume, Page:

Chemical Engineering Research and Design Volume 77, Issue 7, Pages 627–632

Year of Publication:

1999

Link:

http://www.sciencedirect.com/science/article/pii/S0263876299718332

Authors:

H. Mustafa

Chemical Engineering Department, An-Najah National University, Nablus, Palestine

Current Affiliation:

Department of Chemical Engineering, Faculty of Engineering and Informtation Technology, An-Najah National University, Nablus, Palestine

[email protected]

A. Elhamouz

Chemical Engineering Department, An-Najah National University, Nablus, Palestine

E. Békássy-Molnár

Department of Food Engineering, University of Horticulture and Food, Budapest, Hungary

Preferred Abstract (Original):

New types of vibrating-valve trays with textile valves were investigated to determine their optimal construction. Hydrodynamic and mass transfer measurements were carried out in a pilot plant with different vibrating-valve and conventional valve trays under identical experimental conditions. The total tray pressure drop (ΔP), column efficiency (η), volumetric mass transfer coefficient (K_Ga) and pressure drop per theoretical tray (Δp/N_th) were measured and compared.The high mass transfer rate, the low investment and operating costs, the corrosion and heat resistance make the vibrating-valve trays attractive for gas absorption and air cleaning in environmental protection.

Hydrodynamic Characteristics of Nutter Valve Trays, New Correlations

Sun, 2014-05-11 13:32 — Husni Mustafa Mohammed Odeh

Journal Title, Volume, Page:

Chemical Engineering Research and Design Volume 75, Issue 6, Pages 620–624

Year of Publication:

1997

Link:

http://www.sciencedirect.com/science/article/pii/S0263876297715788

Authors:

H. Mustafa

Chemitechnik - Pharma Engineering Ltd, Budapest, Hungary

Current Affiliation:

Department of Chemical Engineering, Faculty of Engineering and Informtation Technology, An-Najah National University, Nablus, Palestine

[email protected]

E. Békássy-Molnár

Department of Food Engineering, University of Horticulture and Food, Budapest, Hungary

Preferred Abstract (Original):

Hydrodynamic parameters were measured in a Nutter valve tray simulation column. The clear liquid height was determined in different operating regimes (foam + mixed and spray regimes) and new formulas were developed as functions of weir height and flow parameter.
New correlations were developed, as functions of geometrical and operating parameters, for the total liquid hold-up and the relative froth density.

Hydrodynamics and Mass Transfer of Textile Vibrating-Valve Trays

Tue, 2013-02-19 17:19 — Amer M EL-Hamouz

Journal Title, Volume, Page:

Trans IChemE, vol. 77, part A, 627, (1999).

Year of Publication:

1999

Link:

http://www.sciencedirect.com/science/article/pii/S0263876299718332

Authors:

A. Elhamouz

Chemical Engineering Department, An-Najah National Uni V ersity, P.O. Box 7, Nablus, Palestine

Current Affiliation:

Chemical Engineering Department, An-Najah National Uni V ersity, P.O. Box 7, Nablus, Palestine

[email protected]

H. Mustafa

Chemical Engineering Department, An-Najah National Uni V ersity, P.O. Box 7, Nablus, Palestine

E. Békássy-Molnár

Department of Food Engineering, University of Horticulture and Food, Budapest, Hungary

Preferred Abstract (Original):

New types of vibrating-valve trays with textile valves were investigated to determine their optimal construction. Hydrodynamic and mass transfer measurements were carried out in a pilot plant with different vibrating-valve and conventional valve trays under identical experimental conditions. The total tray pressure drop (ΔP), column efficiency (η), volumetric mass transfer coefficient (KGa) and pressure drop per theoretical tray (Δp/Nth) were measured and compared. The high mass transfer rate, the low investment and operating costs, the corrosion and heat resistance make the vibrating-valve trays attractive for gas absorption and air cleaning in environmental protection.