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Synthesis, identification, thermal analysis, computational, and antibacterial studies of Z-N'-(5-bromothiophen-2-yl)methylene)nicotinohydrazide

Sun, 2016-02-21 12:57 — Ahmad A. Abu-Obaid
Journal Title, Volume, Page: 
Moroccan Journal of Chemistry, Vol 4, No 1 (2016)
Year of Publication: 
2016
Link: 
http://revues.imist.ma/?journal=morjchem&page=article&op=view&path[]=4183
Authors: 
Yahya Hussam
Ahmad Abu-Obaid
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
[email protected]
Ashraf Sawafta
Dyala Abu-Aladel
I. Asadi Ahmad
Rami Shariah
Tasneem Alayed
Ismail Warad
Preferred Abstract (Original): 

N'-((5-bromothiophen-2-yl)methylene)nicotinohydrazide Schiff  base was isolated  and characterized as Z-isomer. Ethanoic reflux condensation of equivalent  amount of nicotinohydrazideand with 5-bromothiophene-2-carbaldehyde produced  the desired compound in good yield. The condensation reaction was monitored by FT-IR and UV-visible as well as DFT calculation. The structure of desired compound wasexperimentally analyzed based on: elemental analysis, EI-Ms, UV-visible, FT-IR spectral, TG/DTG and 1H-NMR.DFT-computational calculation supportedZ- isomer as favorited product over E one, good accordance between experimental and theoretical calculated were recorded. The antibacterial results obtained using the desired compound indicates a promising result against human pathogenic bacteria.

warad's picture

Synthesis, Identification, Thermal Analysis, Computational, And Antibacterial Studies of Z-N'-(5-Bromothiophen-2-yl)Methylene)Nicotinohydrazid

Thu, 2016-01-28 12:10 — Ismail Warad
Journal Title, Volume, Page: 
Moroccan Journal of Chemistry 4(1),259-269
Year of Publication: 
2016
Link: 
http://revues.imist.ma/?journal=morjchem&page=article&op=view&path[]=4183
Authors: 
Hussam Yahya
Current Affiliation: 
Department of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine
Ahmad Abu-Obaid
Current Affiliation: 
)Department of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine
Ashraf Sawafta
Current Affiliation: 
Biology and Biotechnology Department, An-Najah National University, P.O. Box 7, Nablus, Palestine
Dyala Abu-Aladel
Current Affiliation: 
Biology and Biotechnology Department, An-Najah National University, P.O. Box 7, Nablus, Palestine
Ahmad I. Asadi
Current Affiliation: 
)Department of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine
Rami Shariah
Current Affiliation: 
Department of Basic Science, Faculty of Engineering, Applied Science Private University, PO Box 166, Amman 11931, Jordan
Tasneem Alayed
Current Affiliation: 
Department of Basic Science, Faculty of Engineering, Applied Science Private University, PO Box 166, Amman 11931, Jordan
Ismail Warad
Current Affiliation: 
Department of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine
[email protected]
Preferred Abstract (Original): 
N'-((5-bromothiophen-2-yl)methylene)nicotinohydrazide Schiff  base was isolated  and characterized as Zisomer. Ethanoic reflux condensation of equivalent  amount of nicotinohydrazideand with 5bromothiophene-2-carbaldehyde produced  the desired compound in good yield. The condensation reaction was monitored by FT-IR and UV-visible as well as DFT calculation. The structure of desired compound wasexperimentally analyzed based on: elemental analysis, EI-Ms, UV-visible, FT-IR spectral, TG/DTG and 1H-NMR.DFT-computational calculation supportedZ- isomer as favorited product over E one, good accordance between experimental and theoretical calculated were recorded. The antibacterial results obtained using the desired compound indicates a promising result against human pathogenic bacteria.
warad's picture

Synthesis, Spectral, Theoretical and Thermal Analysis of (Z)-1-((5-bromothiophen-2-yl)methylene)-2-(2,4-dinitrophenyl)hydrazine isomer

Mon, 2015-10-26 16:09 — Ismail Warad
Journal Title, Volume, Page: 
Arabian Journal of Chemical and Environmental Research, ISSN: 2458-6544, Vol.2 N2 (2015) 51–57
Year of Publication: 
2015
Authors: 
Hussam Yahya
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Ahmad I. Asadi
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Mohammed A. Al-Nuri
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
RachidSalghi
Shehdeh Jodeh
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
rami shareiah
Ismail Warad
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, P.O. Box 7, Nablus, Palestine
Preferred Abstract (Original): 
(Z)-1-((5-bromothiophen-2-yl)methylene)-2-(2,4-dinitrophenyl)hydrazine Schiff base was prepared by condensing equivalent amount of (2,4-dinitrophenyl)hydrazine with 5-bromothiophene-2-carbaldehyde in ethanol under reflux condition. EA, EI-Ms spectral, IR, TG/DTG, UV-visible and theoretical calculation were used to assign the Z- isomer formed over E one.
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