Synthesis, identification, thermal analysis, computational, and antibacterial studies of Z-N'-(5-bromothiophen-2-yl)methylene)nicotinohydrazide

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Journal Title, Volume, Page: 
Moroccan Journal of Chemistry, Vol 4, No 1 (2016)
Year of Publication: 
Yahya Hussam
Ahmad Abu-Obaid
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Ashraf Sawafta
Dyala Abu-Aladel
I. Asadi Ahmad
Rami Shariah
Tasneem Alayed
Ismail Warad
Preferred Abstract (Original): 

N'-((5-bromothiophen-2-yl)methylene)nicotinohydrazide Schiff  base was isolated  and characterized as Z-isomer. Ethanoic reflux condensation of equivalent  amount of nicotinohydrazideand with 5-bromothiophene-2-carbaldehyde produced  the desired compound in good yield. The condensation reaction was monitored by FT-IR and UV-visible as well as DFT calculation. The structure of desired compound wasexperimentally analyzed based on: elemental analysis, EI-Ms, UV-visible, FT-IR spectral, TG/DTG and 1H-NMR.DFT-computational calculation supportedZ- isomer as favorited product over E one, good accordance between experimental and theoretical calculated were recorded. The antibacterial results obtained using the desired compound indicates a promising result against human pathogenic bacteria.

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