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Synthesis, Identification, Thermal Analysis, Computational, And Antibacterial Studies of Z-N'-(5-Bromothiophen-2-yl)Methylene)Nicotinohydrazid

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Thu, 2016-01-28 12:10 — Ismail Warad
Journal Title, Volume, Page: 
Moroccan Journal of Chemistry 4(1),259-269
Year of Publication: 
2016
Link: 
http://revues.imist.ma/?journal=morjchem&page=article&op=view&path[]=4183
Authors: 
Hussam Yahya
Current Affiliation: 
Department of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine
Ahmad Abu-Obaid
Current Affiliation: 
)Department of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine
Ashraf Sawafta
Current Affiliation: 
Biology and Biotechnology Department, An-Najah National University, P.O. Box 7, Nablus, Palestine
Dyala Abu-Aladel
Current Affiliation: 
Biology and Biotechnology Department, An-Najah National University, P.O. Box 7, Nablus, Palestine
Ahmad I. Asadi
Current Affiliation: 
)Department of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine
Rami Shariah
Current Affiliation: 
Department of Basic Science, Faculty of Engineering, Applied Science Private University, PO Box 166, Amman 11931, Jordan
Tasneem Alayed
Current Affiliation: 
Department of Basic Science, Faculty of Engineering, Applied Science Private University, PO Box 166, Amman 11931, Jordan
Ismail Warad
Current Affiliation: 
Department of Chemistry, Science College, An-Najah National University, P.O. Box 7, Nablus, Palestine
[email protected]
Preferred Abstract (Original): 
N'-((5-bromothiophen-2-yl)methylene)nicotinohydrazide Schiff  base was isolated  and characterized as Zisomer. Ethanoic reflux condensation of equivalent  amount of nicotinohydrazideand with 5bromothiophene-2-carbaldehyde produced  the desired compound in good yield. The condensation reaction was monitored by FT-IR and UV-visible as well as DFT calculation. The structure of desired compound wasexperimentally analyzed based on: elemental analysis, EI-Ms, UV-visible, FT-IR spectral, TG/DTG and 1H-NMR.DFT-computational calculation supportedZ- isomer as favorited product over E one, good accordance between experimental and theoretical calculated were recorded. The antibacterial results obtained using the desired compound indicates a promising result against human pathogenic bacteria.
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