pyrazoles

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Synthesis and Antibacterial Activity of Novel Curcumin Derivatives Containing Heterocyclic Moiety

Journal Title, Volume, Page: 
Iran J Pharm Res., 12(1): 47–56
Year of Publication: 
2013
Authors: 
Adham Abu Taha
Department of Chemistry, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Faculty of Medicine & Health Sciences, Department of Biomedical Sciences, An-Najah National University, Nablus, Palestine
Noha Mehdawi
Department of Chemistry, An-Najah National University, Nablus, Palestine
Othman A. Hamed
Department of Chemistry, An-Najah National University, Nablus, Palestine
Emad M. Hamed
Department of Chemistry, Hashemite University, Zarqa, Jordan
Mohammed A. Al-Nuri
Department of Chemistry, An-Najah National University, Nablus, Palestine
Ayman S. Hussein
College of Pharmacy, Genetics Laboratory, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

A series of curcumin derivatives containing heterocyclic moiety have been synthesized and evaluated for their antibacterial activities. The chemical structures of the synthesized compounds were verified on the basis of spectral data and elemental analyses. Investigation of antimicrobial activity of the derivatives demonstrated the ability to inhibit Gram-positive microorganisms with zone of inhibition ranging from 14-18 mm, MIC ranging between 0.0625 and 0.25 mg/mL. Among all tested derivatives, diazepine 4 exhibited remarkable potency against Gram-positive bacteria S. aureus. An extensive study is underway to optimize the effectiveness of diazepine type of compounds and to determine their mode of action.

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Synthesis and Antibacterial Activity of Novel Curcumin Derivatives Containing Heterocyclic Moiety

Journal Title, Volume, Page: 
Iranian Journal of Pharmaceutical Research (2013), 12 (1):47-56
Year of Publication: 
2013
Authors: 
Othman A. Hamed
Department of Chemistry, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, An-Najah National University, Nablus, Palestine
Noha Mehdawi
Department of Chemistry, An-Najah National University, Nablus, Palestine
Adham Abu Taha
College of Pharmacy, Genetics Laboratory, An-Najah National University, Nablus, Palestine
Emad M. Hamed
Department of Chemistry, Hashemite University, Zarqa, Jordan
Mohammed A. Al-Nuri
Department of Chemistry, An-Najah National University, Nablus, Palestine
Ayman S. Hussein
College of Pharmacy, Genetics Laboratory, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

A series of curcumin derivatives containing heterocyclic moiety have been synthesized and evaluated for their antibacterial activities. The chemical structures of the synthesized compounds were verified on the basis of spectral data and elemental analyses. Investigation of antimicrobial activity of the derivatives demonstrated the ability to inhibit Gram-positive microorganisms with zone of inhibition ranging from 14-18 mm, MIC ranging between 0.0625 and 0.25 mg/mL. Among all tested derivatives, diazepine 4 exhibited remarkable potency against Gram-positive bacteria S. aureus. An extensive study is underway to optimize the effectiveness of diazepine type of compounds and to determine their mode of action.

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