There is a growing trend in utilizing plant extracts and pharmaceutical compounds as corrosion inhibitors. Accurate identification of the essential oil of aerial parts of Pelargonium was obtained using hydrodistillation, gas chromatography and gas chromatography–mass spectrometry. The oil was predominated by citronellol (22.8 %). The inhibitory effect of essential oil and extract of Pelargonium was estimated on the corrosion of mild steel in 1 M hydrochloric acid (HCl) using weight loss, electrochemical impedance spectroscopy (EIS) and Tafel polarization curves. Inhibition was found to increase with increasing concentration of the essential oil and extract of Pelargonium. The effect of temperature on the corrosion behavior of mild steel in 1 M HCl with addition of essential oil and extract was also studied, and the thermodynamic parameters were determined and discussed. Values of inhibition efficiency were calculated from weight loss, Tafel polarization curves, and EIS. All results are in good agreement. Polarization curves showed that essential oil and extract of Pelargonium behave as mixed type inhibitors in HCl (1 M). The results obtained showed that the essential oil and extract of Pelargonium could serve as an effective inhibitor of the corrosion of mild steel in HCl solution. To avoid any unexpected toxicity, the majority of compounds have been studied by using POM analyses.
There is a growing trend in utilizing plant extracts and pharmaceutical compounds as corrosion inhibitors. Accurate identification of the essential oil of aerial parts of Pelargonium was obtained using hydrodistillation, gas chromatography and gas chromatography–mass spectrometry. The oil was predominated by citronellol (22.8 %). The inhibitory effect of essential oil and extract of Pelargonium was estimated on the corrosion of mild steel in 1 M hydrochloric acid (HCl) using weight loss, electrochemical impedance spectroscopy (EIS) and Tafel polarization curves. Inhibition was found to increase with increasing concentration of the essential oil and extract of Pelargonium. The effect of temperature on the corrosion behavior of mild steel in 1 M HCl with addition of essential oil and extract was also studied, and the thermodynamic parameters were determined and discussed. Values of inhibition efficiency were calculated from weight loss, Tafel polarization curves, and EIS. All results are in good agreement. Polarization curves showed that essential oil and extract of Pelargonium behave as mixed type inhibitors in HCl (1 M). The results obtained showed that the essential oil and extract of Pelargonium could serve as an effective inhibitor of the corrosion of mild steel in HCl solution. To avoid any unexpected toxicity, the majority of compounds have been studied by using POM analyses.
A computation model has been developed for the rational design of bioactive
pharmacophore sites as anti-Mycobacterium Tuberculosis (MT) and anti-Trypanosoma cruzi
(TC) candidates. The 40 compounds 1-40 analyzed have been previously screened for their
antitubercular and antitrypanosomal activity. The highest anti-Trypanosoma cruzi (TC)
activity is obtained for compounds 8 and 18 which exhibited low IC50 values (9.2 and 10.8
M), almost equal to clinical drug, Nifurtimox (7.7 M; 100% Inhib.). This could be
attributed to the existence of two synergic (O---N-) and (O---O-) anti-Tryposomal
phramacophore sites. In contrast to compounds 8 and 18 which contain electro-attractor
groups (R1, R2 = F), analogue compounds 1 and 13 with electro-donor or only hydrogen (R1,
R2 = CH3, H) shows best antibacterial activity (MIC = 0.977 and 1.190 g/mL) very close to
antitubercular activity of Rifampicin (MIC = 0.125 g/mL). This could be attributed to the
existence of (O---NH+) antibacterial phramacophore site.