Pro-drugs

Journal Title, Volume, Page:

Research on Chemical Intermediates, Volume 39, Issue 3 , pp 1227-1244

Year of Publication:

2013

Link:

http://link.springer.com/article/10.1007/s11164-012-0679-6

Authors:

Taibi Ben Hadda

Laboratoire Chimie Matériaux, Faculté des Sciences, Université Med. I, Oujda, Morocco

[email protected]

Teffaha Fergoug

Laboratoire de Chimie Physique des Biomolécules et Interfaces biologiques, Faculté des Sciences de la Nature et de la Vie, Université de Mascara, 29000, Mascara, Algeria

Ismail Warad

Department of Chemistry, Science College, King Saud University, P. O. Box 2455, Riyadh, 11451, Saudi Arabia

Current Affiliation:

Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine

[email protected]

Vijay Masand

Department of Chemistry, Vidyabharati College of Pharmacy, Camp Amaravati, Maharashtra, India

Javed Sheikh

National Environmental Engineering Research Institute, Nagpur, 440020, India

Preferred Abstract (Original):

This paper surveys the various naturally occurring flavonoids that have been isolated from different natural sources. This is the first petra/osiris/molinspiration (POM) analysis published on this topic. The present study furnishes an overview of the 32 flavonoids and anti-HIV-Integrase activity of their metabolite species. The aqueous and/or ethanol extraction of flavonoids have often been used in traditional medicine, and therefore have also been studied for their antitumor, antioxidant, antiviral, anti-algal, antimicrobial, cytotoxic and anti-inflammatory, and significant hepatoprotective and cardiovascular activity without any criteria of selection. Here, on the basis of POM analyses, a simple, economic, quick and efficient bioinformatic platform, it now becomes easy and possible to predict and optimize flavonoids bioactivity.

An-Najah Staff

POM as a Quick Bioinformatic Platform to Select Flavonoids and Their Metabolites as Potential and Efficient HIV-1 Integrase Inhibitors