MMAS

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Relationship of Treatment Satisfaction to Medication Adherence: Findings From a Cross-Sectional Survey Among Hypertensive Patients In Palestine

Journal Title, Volume, Page: 
Health and Quality of Life Outcomes 2013, 11:191
Year of Publication: 
2013
Authors: 
Sa’ed H Zyoud
Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Samah W Al-Jabi
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Waleed M Sweileh
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Donald E Morisky
Department of Community Health Sciences UCLA School of Public Health, Los Angeles, CA, USA
Preferred Abstract (Original): 

Background: The concepts of medication adherence and Treatment satisfactions are commonly used in clinical research for assessing pharmaceutical care and improving treatment outcomes. Generally, one would expect a positive relationship between the two concepts. The objectives of this study were to investigate the factors associated with adherence to antihypertensive therapy among hypertensive patients and to assess the relationship between antihypertensive medication adherence and treatment satisfaction.
Methods: A cross-sectional study was conducted, adopting the Morisky eight-item Medication Adherence Scale (MMAS) for the assessment of medication adherence and using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4) for the assessment of treatment satisfaction. Descriptive and comparative statistics were used to describe socio-demographic and disease-related characteristics of the patients. All analyses were performed using SPSS v 15.0.
Results: Four hundred and ten hypertensive patients were enrolled in the study. The mean age of participants was 58.38 ± 10.65 years; 52% were female and 36.8% had low antihypertensive medication adherence. There was a significant difference in the mean scores in the Effectiveness (p < 0.001), Convenience (p < 0.001), and Global Satisfaction (p < 0.001) domains, but not in the Side Effects (p = 0.466) domain among patients with different levels of adherence. After adjustment for covariates using multiple linear regression, global treatment satisfaction was still statistically significantly (p = 0.001) associated with medication adherence.
Conclusions: Low treatment satisfaction may be an important barrier for achieving high rates of adherence to treatment. These study findings could be helpful in clinical practice, mainly in the early treatment of hypertensive patients, at a point where improving treatment satisfaction is still possible.

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Health-Related Quality of Life Associated With Treatment Adherence in Patients with Hypertension: A Cross-Sectional Study

Journal Title, Volume, Page: 
International Journal of Cardiology Volume 168, Issue 3 , Pages 2981-2983, 3 October 2013
Year of Publication: 
2013
Authors: 
Sa'ed H. Zyoud
Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Samah W. Al-Jabi
Department of Clinical Pharmacy and Pharmacotherapy, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Waleed M.Sweileh
Department of Pharmacology and Toxicology, College of Medicine and H ealth Sciences, An-Najah National University, Nablus, Palestine
Aysha H. Wildali
PharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Hanan M. Saleem
Hayat A. Aysa
PharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Mohammad A. Badwan
PharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Rahmat Awang
WHO Collaborating Centre for Drug Information, National Poiso n Centre, Universiti Sains Malaysia (USM), Penang, Malaysia
Donald E Morisky
Department of Community Health Sciences, UCLA S chool of Public Health, Los Angeles, CA, USA
Preferred Abstract (Original): 

Objective: The aim of this study was to assess the relationship between antihypertensive medication adherence and HRQoL. Methods: A cross-sectional study was conducted, adopting the Morisky eight-item Medication Adherence Scale (MMAS) for the assessment of medication adherence and using the European Quality of Life scale (EQ-5D-5L) for the assessment of HRQoL. Descriptive and comparative statistics were used to describe socio-demographic and disease-related characteristics of the patients. All analyses were performed using SPSS v 15.0.
Results: Four hundred and ten hypertensive patients were enrolled in the study. The mean age of participants was 58.38 ± 10.65 years; 52% were female and 36.8% had low antihypertensive medication adherence. Patients with a high adherence rate had the highest HRQoL scores compared with those with a low or medium adherence rate (Kruskal–Wallis test; p < 0.05). After adjustment for covariates using multiple regression, HRQoL was still statistically significantly associated with medication adherence (p = 0.001). Conclusions: Low HRQoL may be an important barrier to achieving high rates of adherence to treatment. These study findings could be helpful in clinical practice, mainly in the early treatment of hypertensive patients, at a point where improving HRQoL is still possible.

Waleed Sweileh's picture

Health-Related Quality of Life Associated with Treatment Adherence in Patientswith Hypertension: A Cross-Sectional Study

Journal Title, Volume, Page: 
Int J Cardiol. 2013 May 3. pii: S0167-5273(13)00692-X. doi: 10.1016/j.ijcard.2013.04.105. [Epub ahead of print]
Year of Publication: 
2013
Authors: 
Waleed M. Sweileh
Department of Pharmacology and Toxicology, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Current Affiliation: 
College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Sa'ed H. Zyoud
Poison Control and Drug Information Center (PCDIC), College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Samah W. Al-Jabi
Department of Clinical Pharmacy and Pharmacotherapy, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Aysha H. Wildali
PharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Hanan M. Saleem
PharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Hayat A. Aysa
PharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Mohammad A. Badwan
PharmD Program, College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Rahmat Awang
WHO Collaborating Centre for Drug Information, National Poison Centre, Universiti Sains Malaysia (USM), Penang, Malaysia
Donald E. Morisky
Department of Community Health Sciences, UCLA School of Public Health, Los Angeles, CA, USA
Preferred Abstract (Original): 

Hypertension is one of the most important risk factors for coronary heart disease, heart failure, renal failure and stroke, and it remains an important public health challenge which contributes to disability, health care costs and mortality [1] and [2]. The concepts of medication adherence and health-related quality of life (HRQoL) are commonly used in clinical research for assessing pharmaceutical care and improving treatment outcomes [3]. Adherence to drug treatment usually refers to the extent to which patients follow the instructions of their physician or health care providers. HRQoL also refers to the physical, psychological and social dimensions of health that are influenced by a person's experiences, beliefs, expectations and perceptions [4]. Generally one would expect a positive relationship between the two concepts. The objective of this study was to examine the relationship between adherence and HRQoL in a hypertensive population. Knowledge of any differences in HRQoL in this population may be helpful in the planning of therapeutic interventions that will ensure desirable HRQoL and not just the control of blood pressure. Knowledge of HRQoL in hypertensive patients and of the relationship between HRQoL and adherence, being a reliable determinant of cardiovascular disease (CVD) events, will be helpful in preventing or reducing the incidence of CVDs.

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