Objective To evaluate the possible in vitro
interaction between ethanolic extracts of Rhus coriaria (R. coriaria)
(seed), Sacropoterium spinosum (S. spinosum) (seed), Rosa
damascena (R. damascene) (flower) and certain known antimicrobial
drugs including oxytetracycline HCl, penicillin G, cephalexin, sulfadimethoxine
as sodium, and enrofloxacin. This synergy study was carried out against 3
clinical strains of multidrug-resistant Pseudomonas aeruginosa (P.
aeruginosa).
Methods Evaluation of synergy interaction between plant extracts and
antimicrobial agents was carried out using microdilution method.
Results The results of this study showed that there is a decrease in the
MIC in case of combination of ethanolic plant extracts and test antimicrobial
agents. The most interesting result was that the combination between R.
coriaria and these antibiotics, showed a high decrease in minimum
inhibitory concentration (MIC), and a strong bactericidal activity against
these strains.
Conclusions These results may indicate that combinations between R.
coriaria extract and these antibiotics could be useful in fighting emerging
drug-resistance P. aeruginosa, which may due to that R. coriaria
extract contain natural inhibitors working by different mechanisms or
inhibiting efflux pumps. Now we have experiments underway leading to the
identification of the active molecules present in R. coriaria. Further,
in vivo experiments are needed to confirm pseudomonal protection.
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