Molecular Epidemiology of Antibiotic-Resistant Escherichia Coli Isolated From Hospitalized Patients with Urinary Tract Infections in Northern Palestine

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Journal Title, Volume, Page: 
Pol J Microbiol.;53(1):23-6 Year of Publication: 2004
Year of Publication: 
2004
Authors: 
Abu-Shanab B
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Adwan K
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Abu-Hasan N
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Adwan G
Department of Biological Sciences, An-Najah N University, Nablus, Palestine
Jarrar N.
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 
Eighty isolates of Escherichia coli were collected in Northern Palestine throughout the 1996 to 2000 period from hospitalized patients with urinary tract infections (UTIs). Resistance rates were ampicillin, 65%; co-trimoxazole, 55%; cefuroxime, 10%; cefotaxime, 7.5%; ceftazidime, 2.5%; ciprofloxacin, 12.5%; gentamicin, 6.25% and amikacin, 1.25%. No imipenem-resistant isolates were identified. To determine whether this was due to intra-hospital transmission of resistant strains, clonal structure of 10 multiple-resistant isolates was examined by genomic DNA fingerprinting by enterobacterial repetitive intergenic concensus-polymerase chain reaction (ERIC-PCR) and all were clonally distinct. Thus, these strains are likely resistant due to convergent acquisition of resistance determinants by genetically unrelated uropathogenic strains rather than epidemic spread of resistant isolates.
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