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adhamtaha's picture

Antipsychotic Medicines Adherence and Satisfaction Among Palestinian People with Schizophrenia

Journal Title, Volume, Page: 
Current Clinical Pharmacology, 7, 1, 49-55(7)
Year of Publication: 
2012
Authors: 
Adham S. Abu Taha
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Faculty of Medicine & Health Sciences, Department of Biomedical Sciences, An-Najah National University, Nablus, Palestine
Waleed M. Sweileh
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University, Nablus, Palestine
Manal S. Ihbesheh
MS. Biochemistry, School of Pharmacy, Department of Biochemistry, An-Najah National University, Nablus, Palestine
Ikhlas S. Jarar
MS. Pharmacology, Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University, Nablus, Palestine
Ansam F. Sawalha
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University, Nablus, Palestine
Sa’ed H. Zyoud
MS Clinical Pharmacy, WHO Collaborating Centre for Drug Information, National Poison Centre, Universiti Sains Malaysia (USM), 11800 Penang, Malaysia
Donald E. Morisky
Doctoral Training in the Social and Behavioral Determinants of Infectious and Chronic Disease Prevention, Department of Community Health Sciences UCLA School of Public Health, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772, USA
Preferred Abstract (Original): 
Background: In Arab and Muslim-dominated countries, spirituality and religiosity shape the belief and practices toward chronic illnesses. No previous studies were published to assess adherence to and satisfaction with antipsychotic medications in persons with schizophrenia in the Arab world. 

Objective: To assess medication adherence and treatment satisfaction with antipsychotics in a sample of Palestinian people with schizophrenia. 

Methodology: Medication adherence was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8). Treatment satisfaction was assessed using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Psychiatric symptoms were assessed using the expanded Brief Psychiatric Rating Scale (BPRS-E). Data were entered and statistically analyzed using SPSS 16 for windows. 

Results: A convenience sample of 131 persons with schizophrenia was studied. Based on MMAS-8, 44 persons (33.6%) had a low rate, 58 (44.3%) had a medium rate and 29 (22.1%) had a high rate of adherence. Age was significantly correlated (P=0.028) with adherence score. However, variables like use of monotherapy or atypical or depot antipsychotics were not significantly associated with higher adherence. The means of satisfaction with regard to effectiveness, side effects, convenience and global satisfaction were 72.6 ± 20.5, 67.9 ± 31.47, 63.2 ± 14.3 and 63.1 ± 18.8 respectively. There was a significant difference in the means of effectiveness (P<0.01), convenience (P<0.01), global satisfaction (P<0.01), but not side effects domains (P=0.1) among persons with different levels of adherence. Furthermore, there was a significant difference in the means of positive symptom score (P<0.01), manic (P<0.01) and depression (P<0.01) but not negative symptom score (P=0.4) among persons with different levels of adherence. 

Conclusions: Medication nonadherence was common and was associated with low treatment satisfaction scores and poor psychiatric scores. Medication related factors had insignificant effects on adherence scores.
Waleed Sweileh's picture

Antipsychotic Medication Adherence and Satisfaction Among Palestinian People with Schizophrenia

Journal Title, Volume, Page: 
Current Clinical Pharmacology
Year of Publication: 
2012
Authors: 
Sweileh WM
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University, Nablus, Palestine
Current Affiliation: 
College of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Jarar IS
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University, Nablus, Palestine
Sawalha AF
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University, Nablus, Palestine
Abu Taha AS
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University, Nablus, Palestine
Zyoud SH
MS Clinical Pharmacy, WHO Collaborating Centre for Drug Information, National Poison Centre, Universiti Sains Malaysia (USM), 11800 Penang, Malaysia
Morisky DE.
Doctoral Training in the Social and Behavioral Determinants of Infectious and Chronic Disease Prevention, Department of Community Health Sciences UCLA School of Public Health, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772, USA
Manal S. Ihbesheh
MS. Biochemistry, School of Pharmacy, Department of Biochemistry, An-Najah National University, Nablus, Palestine;
Preferred Abstract (Original): 

In Arab and Muslim-dominated countries, spirituality and religiosity shape the belief and practices toward chronic illnesses. No previous studies were published to assess adherence to and satisfaction with antipsychotic medications in persons with schizophrenia in the Arab world. Objective: To assess medication adherence and treatment satisfaction with antipsychotics in a sample of Palestinian people with schizophrenia. Methodology: Medication adherence was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8). Treatment satisfaction was assessed using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Psychiatric symptoms were assessed using the expanded Brief Psychiatric Rating Scale (BPRS-E). Data were entered and statistically analyzed using SPSS 16 for windows. Results: A convenience sample of 131 persons with schizophrenia was studied. Based on MMAS-8, 44 persons (33.6%) had a low rate, 58 (44.3%) had a medium rate and 29 (22.1%) had a high rate of adherence. Age was significantly correlated (P=0.028) with adherence score. However, variables like use of monotherapy or atypical or depot antipsychotics were not significantly associated with higher adherence. The means of satisfaction with regard to effectiveness, side effects, convenience and global satisfaction were 72.6 ± 20.5, 67.9 ± 31.47, 63.2 ± 14.3 and 63.1 ± 18.8 respectively. There was a significant difference in the means of effectiveness (P<0.01), convenience (P<0.01), global satisfaction (P<0.01), but not side effects domains (P=0.1) among persons with different levels of adherence. Furthermore, there was a significant difference in the means of positive symptom score (P<0.01), manic (P<0.01) and depression (P<0.01) but not negative symptom score (P=0.4) among persons with different levels of adherence. Conclusions: Medication nonadherence was common and was associated with low treatment satisfaction scores and poor psychiatric scores. Medication related factors had insignificant effects on adherence scores.

saedzyoud's picture

Antipsychotic Medication Adherence and Satisfaction Among Palestinian People with Schizophrenia

Journal Title, Volume, Page: 
Current Clinical Pharmacology, Volume 7, Number 1, February 2012 , pp. 49-55(7)
Year of Publication: 
2012
Authors: 
Waleed M. Sweileh
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Manal S. Ihbesheh
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Ikhlas S. Jarar
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Ansam F. Sawalha
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Sa'ed H. Zyoud
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Donald E. Morisky
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Background: In Arab and Muslim-dominated countries, spirituality and religiosity shape the belief and practices toward chronic illnesses. No previous studies were published to assess adherence to and satisfaction with antipsychotic medications in persons with schizophrenia in the Arab world. Objective: To assess medication adherence and treatment satisfaction with antipsychotics in a sample of Palestinian people with schizophrenia. Methodology: Medication adherence was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8). Treatment satisfaction was assessed using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Psychiatric symptoms were assessed using the expanded Brief Psychiatric Rating Scale (BPRS-E). Data were entered and statistically analyzed using SPSS 16 for windows. Results: A convenience sample of 131 persons with schizophrenia was studied. Based on MMAS-8, 44 persons (33.6%) had a low rate, 58 (44.3%) had a medium rate and 29 (22.1%) had a high rate of adherence. Age was significantly correlated (P=0.028) with adherence score. However, variables like use of monotherapy or atypical or depot antipsychotics were not significantly associated with higher adherence. The means of satisfaction with regard to effectiveness, side effects, convenience and global satisfaction were 72.6 ± 20.5, 67.9 ± 31.47, 63.2 ± 14.3 and 63.1 ± 18.8 respectively. There was a significant difference in the means of effectiveness (P < 0.01), convenience (P < 0.01), global satisfaction (P < 0.01), but not side effects domains (P=0.1) among persons with different levels of adherence. Furthermore, there was a significant difference in the means of positive symptom score (P < 0.01), manic (P < 0.01) and depression (P < 0.01) but not negative symptom score (P=0.4) among persons with different levels of adherence. Conclusions: Medication nonadherence was common and was associated with low treatment satisfaction scores and poor psychiatric scores. Medication related factors had insignificant effects on adherence scores

saedzyoud's picture

Antipsychotic Medication Adherence and Satisfaction Among Palestinian People With Schizophrenia

Journal Title, Volume, Page: 
Current Clinical Pharmacology: 2012 Feb 1;7(1):49-55.
Year of Publication: 
2012
Authors: 
Waleed M. Sweileh
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University,Nablus, Palestine
Manal S. Ihbesheh
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University,Nablus, Palestine
Ikhlas S. Jarar
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University,Nablus, Palestine
Ansam F. Sawalha
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University,Nablus, Palestine
Adham S. Abu Taha
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University,Nablus, Palestine
Sa'ed H. Zyoud
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University,Nablus, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Donald E. Morisky
Department of Pharmacology and Toxicology, School of Pharmacy, An-Najah National University,Nablus, Palestine
Preferred Abstract (Original): 

Background: In Arab and Muslim-dominated countries, spirituality and religiosity shape the belief and practices toward chronic illnesses. No previous studies were published to assess adherence to and satisfaction with antipsychotic medications in persons with schizophrenia in the Arab world.
Objective: To assess medication adherence and treatment satisfaction with antipsychotics in a sample of Palestinian people with schizophrenia. Methodology: Medication adherence was assessed using the 8-item Morisky Medication Adherence Scale (MMAS-8). Treatment satisfaction was assessed using the Treatment Satisfaction Questionnaire for Medication (TSQM 1.4). Psychiatric symptoms were assessed using the expanded Brief Psychiatric Rating Scale (BPRS-E). Data were entered and statistically analyzed using SPSS 16 for windows. Results: A convenience sample of 131 persons with schizophrenia was studied. Based on MMAS-8, 44 persons (33.6%) had a low rate, 58 (44.3%) had a medium rate and 29 (22.1%) had a high rate of adherence. Age was significantly correlated (P=0.028) with adherence score. However, variables like use of monotherapy or atypical or depot antipsychotics were not significantly associated with higher adherence. The means of satisfaction with regard to effectiveness, side effects, convenience and global satisfaction were 72.6 ± 20.5, 67.9 ± 31.47, 63.2 ± 14.3 and 63.1 ± 18.8 respectively. There was a significant difference in the means of effectiveness (P < 0.01), convenience (P < 0.01), global satisfaction (P < 0.01), but not side effects domains (P=0.1) among persons with different levels of adherence. Furthermore, there was a significant difference in the means of positive symptom score (P < 0.01), manic (P < 0.01) and depression (P < 0.01) but not negative symptom score (P=0.4) among persons with different levels of adherence.
Conclusions: Medication nonadherence was common and was associated with low treatment satisfaction scores and poor psychiatric scores. Medication related factors had insignificant effects on adherence scores

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