Ru(II) complex | An-Najah Staff

Crystal Structureoftrans-Dichloro(1,4-bis-(diphenylphosphino)butane)- (N,N'-1,2-dimethyl-ethanediamine)ruthenium(II), C32H40Cl2N2P2Ru

Thu, 2013-03-14 17:38 — Ismail Warad

Journal Title, Volume, Page:

Z. Kristallog r. NCS 227 (2012) 379-382 / DOI 10.1524/ncrs.2012. 0192

Year of Publication:

2012

Link:

http://www.oldenbourg-link.com/doi/pdf/10.1524/ncrs.2012.0192

Authors:

Hanan Al -Hussain

Department of chemistry, College of Science, King Saud University ,P.O.2 455, Riyadh 11451, Saudi Arabia

Ismail Warad

Department of chemistry, College of Science, King Saud University ,P.O.2 455, Riyadh 11451, Saudi Arabia

Current Affiliation:

Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine

[email protected]

Hamda Al-Enzi

Department of chemistry, College of Science, King Saud University ,P.O.2 455, Riyadh 11451, Saudi Arabia

Khalid Al-Farhan

Department of chemistry, College of Science, King Saud University ,P.O.2 455, Riyadh 11451, Saudi Arabia

Mohamed Ghazzali

Department of chemistry, College of Science, King Saud University ,P.O.2 455, Riyadh 11451, Saudi Arabia

[email protected]

Preferred Abstract (Original):

Molecular rutheniumcomplexesarecurrentlyusedascatalysts to promote avariety of reactions with novel activation routes. Coordination and organometallic complexes of rutheniumhave unfolded wide possibilities for acollection of catalytic organic processes, taking advantages of the development in the

A Novel Ru(II) Complex Derived from Hydroxydiamine as A Potential Antitumor Agent: Synthesis and Structural Characterization

Wed, 2013-03-13 17:15 — Ismail Warad

Journal Title, Volume, Page:

Inorganic Chemistry Communications Volume 20, June 2012, Pages 252–258

Year of Publication:

2012

Link:

http://www.sciencedirect.com/science/article/pii/S138770031200130X

Authors:

Mohammad Azam

Department of Chemistry, King Saud University, P.O. Box 2455, Riyadh 11451, KSA

[email protected]

Ismail Warad

Department of Chemistry, King Saud University, P.O. Box 2455, Riyadh 11451, KSA

Current Affiliation:

Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine

Saud Al-Resayes

Department of Chemistry, King Saud University, P.O. Box 2455, Riyadh 11451, KSA

Mohammad Shakir

Department of Chemistry, Aligarh Muslim University, Aligarh 202002 India

M.F. Ullah

Department of Pathobiology, University of Tennessee, 2407 River Drive, Knoxvilli, TN 37996, USA

Aamir Ahmad

Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI48201, USA

Fazlul H. Sarkar

Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI48201, USA

Preferred Abstract (Original):

A novel Ru(II)-Schiff base complex has been synthesized by the interaction of ligand, 1,3-bis{[(E)-(2-chlorophenyl)methylidene]amino}-2-propanol, L with [RuCl2(PPh3)3]. The structure of ligand, L has been determined on the basis of X-ray diffraction while the geometry of the Ru(II) complex has been ascertained by FT-IR, 1H, 13 C{1H}, 31P{1H} NMR and UV–vis studies. The in vitro antitumor activity of these compounds was assessed by examining their ability to inhibit cell proliferation against human breast and pancreatic cancer cell lines. The results show a dose-dependent anti-proliferative effect and induction of apoptotic cell death in both the cancer cell lines, thus indicating pharmacological significance of Ru(II) complex against cancer.