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A Novel Ru(II) Complex Derived from Hydroxydiamine as A Potential Antitumor Agent: Synthesis and Structural Characterization

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Wed, 2013-03-13 17:15 — Ismail Warad
Journal Title, Volume, Page: 
Inorganic Chemistry Communications Volume 20, June 2012, Pages 252–258
Year of Publication: 
2012
Link: 
http://www.sciencedirect.com/science/article/pii/S138770031200130X
Authors: 
Mohammad Azam
Department of Chemistry, King Saud University, P.O. Box 2455, Riyadh 11451, KSA
[email protected]
Ismail Warad
Department of Chemistry, King Saud University, P.O. Box 2455, Riyadh 11451, KSA
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Saud Al-Resayes
Department of Chemistry, King Saud University, P.O. Box 2455, Riyadh 11451, KSA
Mohammad Shakir
Department of Chemistry, Aligarh Muslim University, Aligarh 202002 India
M.F. Ullah
Department of Pathobiology, University of Tennessee, 2407 River Drive, Knoxvilli, TN 37996, USA
Aamir Ahmad
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI48201, USA
Fazlul H. Sarkar
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI48201, USA
Preferred Abstract (Original): 
A novel Ru(II)-Schiff base complex has been synthesized by the interaction of ligand, 1,3-bis{[(E)-(2-chlorophenyl)methylidene]amino}-2-propanol, L with [RuCl2(PPh3)3]. The structure of ligand, L has been determined on the basis of X-ray diffraction while the geometry of the Ru(II) complex has been ascertained by FT-IR, 1H, 13 C{1H}, 31P{1H} NMR and UV–vis studies. The in vitro antitumor activity of these compounds was assessed by examining their ability to inhibit cell proliferation against human breast and pancreatic cancer cell lines. The results show a dose-dependent anti-proliferative effect and induction of apoptotic cell death in both the cancer cell lines, thus indicating pharmacological significance of Ru(II) complex against cancer.
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