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HIV-1 Co-Receptor CCR5 And CCR2 Mutations Among Greeks

Tue, 2010-04-20 19:15 — Ghaleb Adwan
Journal Title, Volume, Page: 
FEMS Immunology and Medical Microbiology 28 (2000) 87-89
Year of Publication: 
2000
Link: 
http://onlinelibrary.wiley.com/doi/10.1111/j.1574-695X.2000.tb01461.x/abstract;j...
Authors: 
Ghaleb M. Adwan
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece
Current Affiliation: 
Department of Biology, Faculty of Science, An-Najah National University, Nablus. Palestine
[email protected]
Anna Papa
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece
Evagelia Papadimitriou
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece
Stella Alexiou
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece
Jonathan P. Clewley
Central Public Health Laboratory, London, UK
Ioannis Ntoutsos
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece
Nikos Malissiovas
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece
Antonis Antoniadis
National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece
Preferred Abstract (Original): 

The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5v32 allele among the HIV-negative subjects was 0.052, while it was approximately twofold lower among the seropositives, suggesting that the heterozygous genotype confers a partial resistance to the HIV infection. No significant difference in CCR2 allele frequency between the two groups was observed.

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