HIV-1 Co-Receptor CCR5 And CCR2 Mutations Among Greeks

Journal Title, Volume, Page:

FEMS Immunology and Medical Microbiology 28 (2000) 87-89

Year of Publication:

2000

Link:

http://onlinelibrary.wiley.com/doi/10.1111/j.1574-695X.2000.tb01461.x/abstract;j...

Authors:

Ghaleb M. Adwan

National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece

Current Affiliation:

Department of Biology, Faculty of Science, An-Najah National University, Nablus. Palestine

[email protected]

Anna Papa

National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece

Evagelia Papadimitriou

National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece

Stella Alexiou

National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece

Jonathan P. Clewley

Central Public Health Laboratory, London, UK

Ioannis Ntoutsos

National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece

Nikos Malissiovas

National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece

Antonis Antoniadis

National AIDS Reference Laboratory of Northern Greece, Department of Microbiology, School of Medicine, Aristotelian University of Thessaloniki, Thessaloniki, Greece

Preferred Abstract (Original):

The frequency of CCR5 and CCR2 alleles in human immunodeficiency virus (HIV)-positive and HIV-negative populations of Northern Greece was investigated. The frequency of the CCR5v32 allele among the HIV-negative subjects was 0.052, while it was approximately twofold lower among the seropositives, suggesting that the heterozygous genotype confers a partial resistance to the HIV infection. No significant difference in CCR2 allele frequency between the two groups was observed.

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HIV-1 Co-Receptor CCR5 And CCR2 Mutations Among Greeks