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Synthesis and Structural Characterization of Pd(II) Complexes Derived from Perimidine Ligand and Their in Vitro Antimicrobial Studies

Thu, 2013-05-09 10:59 — Ismail Warad
Journal Title, Volume, Page: 
Journal of Molecular Structure Volume 1047, 2013, Pages 48–54
Year of Publication: 
2013
Link: 
http://www.sciencedirect.com/science/article/pii/S0022286013003840
Authors: 
Mohammad Azam
Department of Chemistry, King Saud University, P. O. Box 2455, Riyadh 11451, KSA
[email protected]
Ismail Warad
Department of Chemistry, King Saud University, P. O. Box 2455, Riyadh 11451, KSA
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Saud I. Al-Resayes
Department of Chemistry, King Saud University, P. O. Box 2455, Riyadh 11451, KSA
Nabil Alzaqri
Department of Chemistry, King Saud University, P. O. Box 2455, Riyadh 11451, KSA
Mohammad Rizwan Khan
Department of Chemistry, King Saud University, P. O. Box 2455, Riyadh 11451, KSA
Raghavaiah Pallepogu
School of Chemistry, University of Hyderabad, Hyderabad 500046, India
Sourabh Dwivedi
Department of Zoology, King Saud University, P. O. Box 2455, Riyadh 11451, KSA
Javed Musarrat
Department of Ag. Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh 202002 India
Mohammad Shakir
Department of Chemistry, Aligarh Muslim University, Aligarh 202002 India
Preferred Abstract (Original): 
A novel series of Pd(II) complexes derived from 2-thiophenecarboxaldehyde and 1,8-diaminonaphthalene has been synthesized and characterized by various physico-chemical and spectroscopic techniques viz., elemental analyses, IR, UV-Vis, 1H and 13C NMR spectroscopy, and ESI-mass spectrometry. The structure of ligand, 2-(2-thienyl)-2,3-dihydro-1H-perimidine has been ascertained on the basis of single crystal X-Ray diffraction. All Pd(II) complexes together with the corresponding ligand have been evaluated for their ability to suppress the in vitro growth of microbes, E. coli, S. aureus, P. aeruginosa, Citrobacter sp., B. subtilis and S. acidaminiphila and results show that Pd(II) complexes have more significant antimicrobial activity than their corresponding ligand. Fluorescence spectroscopic measurements clearly support that both of the Pd(II) complexes show significant DNA binding with calf thymus DNA.
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