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Spectroscopic Studies on the Binding of Some Fluoroquinolones with DNA

Journal Title, Volume, Page: 
Journal of Applied Sciences 12/2013; 1(5):179-184
Year of Publication: 
Ibrahim Abu-Shqair
An-Najah National University
Nizam Diab
Arab American University- Jenin
Radi Salim
An-Najah National University
Mohammad Al-Subu
An-Najah National University
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

UV-visible spectroscopic methods were used to study the interaction of some fluoroquinolones with calf-thymus DNA. The binding constants of drug-DNA complexes were evaluated and the nature of binding of these drugs with DNA were elucidated. The results suggested that fluoroquinolones bind to DNA through an electrostatic mode of interaction with partial intercalation.

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