DNA binding

Journal Title, Volume, Page:

Journal of Applied Sciences 12/2013; 1(5):179-184

Year of Publication:

2013

Authors:

Ibrahim Abu-Shqair

An-Najah National University

Nizam Diab

Arab American University- Jenin

Radi Salim

An-Najah National University

Mohammad Al-Subu

An-Najah National University

Current Affiliation:

Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine

[email protected]

Preferred Abstract (Original):

UV-visible spectroscopic methods were used to study the interaction of some fluoroquinolones with calf-thymus DNA. The binding constants of drug-DNA complexes were evaluated and the nature of binding of these drugs with DNA were elucidated. The results suggested that fluoroquinolones bind to DNA through an electrostatic mode of interaction with partial intercalation.

An-Najah Staff

Spectroscopic Studies on the Binding of Some Fluoroquinolones with DNA