An-Najah Staff

This study aimed to evaluate antibacterial and antifungal activities and exhaustive extraction yields of the aqueous and organic extracts of Verbascum sinuatum L., against possible human pathogens, which are the fungus Candida albicans, gram positive bacteria Bacillus subtilis, Staphylococcus aureus Staphylococcus epidermidis and the gram negative bacteria Eschrichia coli and Pseudomonas aeruginosa. Well diffusion method was used in screening antimicrobial activity for the plant extracts, in which the diameters of inhibition zones were measured and compared to a positive control. Serial dilution method was used for measuring the minimum inhibition concentrations for each microorganism. In well diffusion method, the plant’s aqueous extract has antimicrobial activity to all the tested organisms except Pseudomonas aeruginosa and Candida albicans, with variable diameters of inhibition zone. The percent inhibition compared to the positive control imipenem was 39.13% for Staphylococcus aureus, 37.5% for Staphylococcus epidermidis, Eschrichia coli for 30.55% and the least 30.43% for Bacillus subtilis. The organic extract exhibited inhibition activity 26.08% against Bacillus subtilis and 50% against Eschrichia coli. In the serial dilution method, the aqueous extract exhibited inhibition for all the test microorganisms. At initial concentration of 20 mg/ml, the lowest MIC value was for Staphylococcus aureus 1.28 µg/ml, and highest for Staphylococcus epidermidis 4000 µg/ml. The MIC values for Pseudomonas aeruginosa 160 µg/ml, 800 µg/ml for Bacillus subtilis, 800 µg/ml for Eschrichia coli and 32 µg/ml for Candida albicans respectively. This study showed that V. sinuatum extract has a broad spectrum activity against gram positive and gram negative bacteria, as well as anticandidal activity.

Objective: Antioxidant activity of natural compounds in food and in dietary supplements plays an important role in healthy life. Scientific evidences suggest that antioxidants reduce the risk for chronic diseases including cancer, diabetes mellitus and heart diseases.
Methods: The antioxidant activity of wild Cyclamen persicum, Malva sylvestris and Urtica pilulifera leaves and their cultivated species were studied using 2, 2-diphenylpicrylhydrazyl (DPPH) radical scavenging activity and compared to Trolox antioxidant activity. The exhaustive extractions yields for these samples were estimated by using polar and nonpolar solvents.
Results: The results showed that the wild Cyclamen persicum, Malva sylvestris and Urtica pilulifera leaves have higher exhaustive extraction yield and as well the higher antioxidant activity (IC50) comparing with their cultivated species.
Conclusions: Both of cultivated, as well the wild natural growing forms of Cyclamen persicum, Malva sylvestris and Urtica pilulifera are a good source for natural foods supplements, pharmaceutical industry purposes and for organic food rich with antioxidant compounds.

Objective: Antioxidant activity of natural compounds in food and in dietary supplements plays an important role in healthy life. Scientific evidences suggest that antioxidants reduce the risk for chronic diseases including cancer, diabetes mellitus and heart diseases.
Methods: The antioxidant activity of wild Cyclamen persicum, Malva sylvestris and Urtica pilulifera leaves and their cultivated species were studied using 2, 2-diphenylpicrylhydrazyl (DPPH) radical scavenging activity and compared to Trolox antioxidant activity. The exhaustive extractions yields for these samples were estimated by using polar and nonpolar solvents.
Results: The results showed that the wild Cyclamen persicum, Malva sylvestris and Urtica pilulifera leaves have higher exhaustive extraction yield and as well the higher antioxidant activity (IC50) comparing with their cultivated species.
Conclusions: Both of cultivated, as well the wild natural growing forms of Cyclamen persicum, Malva sylvestris and Urtica pilulifera are a good source for natural foods supplements, pharmaceutical industry purposes and for organic food rich with antioxidant compounds.
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 Arum palaestinum Boiss. leaves considered one of the most edible wild plant in Palestine also one of the medicinal plant utilized for treatment various diseases specially cancer. The present study sought to evaluate the exhaustive extract yields percentages for Solomon's Lily (Arum palaestinum Boiss.) leaves from all of the regions in the West Bank/Palestine (Nablus, Jenin, Tubas, Tulkarm, Salpheet, Qalqilya, Ramallah, Jericho, Jerusalem, Bethlehem, Hebron) to investigate the best region in Palestine that have the strongest anticancer activity which can be helpful in manufacturing foods supplements, cosmeceuticals and pharmaceuticals formulations. By using exhaustive extraction method, the yield of organic and water extraction experimental method was assessed, with steeping the plant in ethanol, water and hexane to extract all the chemical ingredients without destroying or changing their chemical constituents. It is found that the best aqueous and organic yields were in Salfeet region (4.8%, 3.24 %, respectively) while the lowest aqueous yield and organic yield was in Jericho (2.64%, 0.76%, respectively). In recommendation for pharmaceutical companies, Salfeet region was the best area for cultivation Arum palaestinum Boiss. plant for manufacturing evidence based standardized pharmacological active pharmaceutical forms also for further scientific researches.
see the full file here

 Arum palaestinum Boiss. leaves considered one of the most edible wild plant in Palestine also one of the medicinal plant utilized for treatment various diseases specially cancer. The present study sought to evaluate the exhaustive extract yields percentages for Solomon's Lily (Arum palaestinum Boiss.) leaves from all of the regions in the West Bank/Palestine (Nablus, Jenin, Tubas, Tulkarm, Salpheet, Qalqilya, Ramallah, Jericho, Jerusalem, Bethlehem, Hebron) to investigate the best region in Palestine that have the strongest anticancer activity which can be helpful in manufacturing foods supplements, cosmeceuticals and pharmaceuticals formulations. By using exhaustive extraction method, the yield of organic and water extraction experimental method was assessed, with steeping the plant in ethanol, water and hexane to extract all the chemical ingredients without destroying or changing their chemical constituents. It is found that the best aqueous and organic yields were in Salfeet region (4.8%, 3.24 %, respectively) while the lowest aqueous yield and organic yield was in Jericho (2.64%, 0.76%, respectively). In recommendation for pharmaceutical companies, Salfeet region was the best area for cultivation Arum palaestinum Boiss. plant for manufacturing evidence based standardized pharmacological active pharmaceutical forms also for further scientific researches.

 Arum palaestinum Boiss. leaves considered one of the most edible wild plant in Palestine also one of the medicinal plant utilized for treatment various diseases specially cancer. The present study sought to evaluate the exhaustive extract yields percentages for Solomon's Lily (Arum palaestinum Boiss.) leaves from all of the regions in the West Bank/Palestine (Nablus, Jenin, Tubas, Tulkarm, Salpheet, Qalqilya, Ramallah, Jericho, Jerusalem, Bethlehem, Hebron) to investigate the best region in Palestine that have the strongest anticancer activity which can be helpful in manufacturing foods supplements, cosmeceuticals and pharmaceuticals formulations. By using exhaustive extraction method, the yield of organic and water extraction experimental method was assessed, with steeping the plant in ethanol, water and hexane to extract all the chemical ingredients without destroying or changing their chemical constituents. It is found that the best aqueous and organic yields were in Salfeet region (4.8%, 3.24 %, respectively) while the lowest aqueous yield and organic yield was in Jericho (2.64%, 0.76%, respectively). In recommendation for pharmaceutical companies, Salfeet region was the best area for cultivation Arum palaestinum Boiss. plant for manufacturing evidence based standardized pharmacological active pharmaceutical forms also for further scientific researches.
see the full file here

Objective: Teucrium polium L. aerial parts have been used by local populations of Palestine for the treatment of various diseases as diabetes mellitus, amoeba, intestinal spasms and diarrhea for that the interest of using this herbal remedy among researchers and populations increased, this study was aimed to evaluate the best area in Palestine that may be considered the best source of collection and cultivation for Teucrium polium plant in the future, to be a good source for manufacturing active pharmaceutical dosage forms from this plant.

Method: The yield of the organic and water extraction method assessed by using exhaustive extraction method, by steeping the plant in ethanol, water and hexane to extract all the chemical ingredients without heating to prevent destroying or changing the plant chemical constituents.

Results: the best aqueous and organic yields were in Bethlehem region (6.4%, 2.6 %), while the lowest aqueous and organic yields were in Qalqilya (4.96%, 1.16%).

Conclusion: We recommended the pharmaceutical companies; Bethlehem region as the best area for cultivation and collection Teucrium plant for manufacturing the best standardized pharmaceutical dosage forms also we recommended the researchers to use the Teucrium plant from this region for their scientific research.