Home

albendazole determination

syaish's picture

Adsorptive Stripping Voltametric Determination of Albendazole at a Hanging Mercury Drop Electrode

Thu, 2014-03-13 14:43 — Sami Yaish
Journal Title, Volume, Page: 
Analytical Letters Volume 32, Issue 15, 1999, pages 2965-2975
Year of Publication: 
1999
Link: 
http://www.tandfonline.com/doi/abs/10.1080/00032719908543020?journalCode=lanl20#...
Authors: 
Ali Z. Abu Zuhri
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus. Palestine
Amjad I. Hussein
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Mohammad Musmar
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Sami Yaish
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
[email protected]
Preferred Abstract (Original): 

Albendazole is determined by differential-pulse adsorptive cathodic stripping voltammetry at a hanging mercury drop electrode using the reduction peak of its copper(II) complex at −0.28V at an accumulation potential 0.0V vs. Ag/AgCl electrode. The optimum conditions of pH, accumulation potential and accumulation time were studied. The calibration graph for the determination of albendazole was linear in the range 3.0X10−8 - 9X10−7M with a relative standard deviation of 2.8%. The detection limit was 1.0X10−8M after 180s accumulation at 0.0V. The effect of common excipients and metal ions on the peak height of albendazole was studied. The presence of Cu2+ ions forms a stable complex with albendazole which is strongly adsorbed at the mercury electrode surface. The method was applied to the determination of the drug in commercially available dosage forms.

2187's picture

Adsorptive Stripping Voltammetric Determination of Albendazole at a Hanging Mercury Drop Electrode

Wed, 2014-01-22 13:30 — Mohammad Musmar
Journal Title, Volume, Page: 
Analytical Letters Volume 32, Issue 15, 1999
Year of Publication: 
1999
Link: 
http://www.tandfonline.com/doi/abs/10.1080/00032719908543020#.Ut-sKbSxXgw
Authors: 
Ali Z. Abu Zuhri
Department of Chemistry, An-Najah National University, Nablus, Palestine
Amjad I. Hussein
Department of Chemistry, An-Najah National University, Nablus, Palestine
Mohammad Musmar
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
[email protected]
Sami Yaish
Department of Chemistry, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Albendazole is determined by differential-pulse adsorptive cathodic stripping voltammetry at a hanging mercury drop electrode using the reduction peak of its copper(II) complex at −0.28V at an accumulation potential 0.0V vs. Ag/AgCl electrode. The optimum conditions of pH, accumulation potential and accumulation time were studied. The calibration graph for the determination of albendazole was linear in the range 3.0X10−8 - 9X10−7M with a relative standard deviation of 2.8%. The detection limit was 1.0X10−8M after 180s accumulation at 0.0V. The effect of common excipients and metal ions on the peak height of albendazole was studied. The presence of Cu2+ ions forms a stable complex with albendazole which is strongly adsorbed at the mercury electrode surface. The method was applied to the determination of the drug in commercially available dosage forms.

Syndicate content