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Adsorptive Stripping Voltametric Determination of Albendazole at a Hanging Mercury Drop Electrode

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Thu, 2014-03-13 14:43 — Sami Yaish
Journal Title, Volume, Page: 
Analytical Letters Volume 32, Issue 15, 1999, pages 2965-2975
Year of Publication: 
1999
Link: 
http://www.tandfonline.com/doi/abs/10.1080/00032719908543020?journalCode=lanl20#...
Authors: 
Ali Z. Abu Zuhri
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus. Palestine
Amjad I. Hussein
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Mohammad Musmar
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Sami Yaish
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Biology and Biotechnology, Faculty of Science, An-Najah National University, Nablus, Palestine
[email protected]
Preferred Abstract (Original): 

Albendazole is determined by differential-pulse adsorptive cathodic stripping voltammetry at a hanging mercury drop electrode using the reduction peak of its copper(II) complex at −0.28V at an accumulation potential 0.0V vs. Ag/AgCl electrode. The optimum conditions of pH, accumulation potential and accumulation time were studied. The calibration graph for the determination of albendazole was linear in the range 3.0X10−8 - 9X10−7M with a relative standard deviation of 2.8%. The detection limit was 1.0X10−8M after 180s accumulation at 0.0V. The effect of common excipients and metal ions on the peak height of albendazole was studied. The presence of Cu2+ ions forms a stable complex with albendazole which is strongly adsorbed at the mercury electrode surface. The method was applied to the determination of the drug in commercially available dosage forms.