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Antibacterial activity of Rosmarinus officinalis L. alone and in combination with cefuroxime against methicillin-resistant Staphylococcus aureus

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Sun, 2013-04-14 16:10 — Awni A. M. Abu-Hijleh
Journal Title, Volume, Page: 
Asian Pacific Journal of Tropical Medicine Volume 3, Issue 2, February 2010, Pages 121–123
Year of Publication: 
2010
Link: 
http://www.sciencedirect.com/science/article/pii/S1995764510600491
Authors: 
Naser Jarrar
Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine
Awni Abu-Hijleh
Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Biology, Faculty of Science, An-Najah National University, Nablus. Palestine
[email protected]
Kamel Adwan
Department of Biology and Biotechnology, An-Najah National University, Nablus, Palestine
Preferred Abstract (Original): 

Objective To determine the antimicrobial activity of rosemary (Rosmarinus officinalis L.) and to investigate the synergistic effects of this extract combined with ceforuxime against methicillin-resistant Staphylococcus aureus (MRSA).
Methods The inhibitory and bactericidal activities of rosemary ethanol extract, alone and in combination with cefuroxime, were studied.
Results  The minimum inhibitory concentrations (MICs) of the ethanol extract of rosemary were in the range of 0.39–3.13 mg/mL. The minimum bactericidal concentrations (MBCs) were usually equal to or double that MICs. The antimicrobial activity of combinations of the ethanol extract of rosemary and cefuroxime indicated their synergistic effects against all MRSAs.
Conclusions  The present work clearly demonstrates that rosemary has a key role in the elevation of susceptibility to β-lactams.

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