Concepts of Genetics

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Genetics 242131


REFERENCES:  Strickberger, Genetics, 3rd edition, 1985  Goodenough, Genetics, 3rd edition, Saunders, 1984  Ayala and Kiger, Modern Genetics, 2nd edition, 1984;  Zubay, Genetics, Benjamin/Cummings, 1987;  Genome, Blackwell, 2003  Turner, P.C., Mclennan, A.G., Bates, A.D. and White, M.R.H. (1998). Instant Notes in Molecular Biology, Viva Books Pvt., Ltd., New Delhi.  Twynan, R.M. (2003). Advanced Molecular Biology. Viva books Pvt. Ltd. New Delhi.  Kannan, N. (2003). Hand Book of Laboratory Culture Medias, Reagents, Stains and Buffers. Panima Publishing Co., New Delhi.

COURSE DESCRIPTION: An introduction to the principles of genetics, including topics from classical Mendelian concepts to the contemporary molecular biology of the gene. Three lecture hours and one three-hour laboratory per week. (3 credits) Course Objectives: 1) Understand the basics of the structure, and function of nucleic acids. 2) Know the basics of DNA replication in prokaryotes and eukaryotes. 3) Know the basics of transcription, translation, transcriptional control, and post-transcriptional control in prokaryotes and eukaryotes. 4) Be familiar with the most common techniques in molecular genetics. 5) Understand the laws of heredity and how they can be used in basic and applied research. 6) Predict the outcome of genetic crosses. 7) Deduce the nature of hereditary systems given the results of genetic crosses. 8) Know how genes are packaged with proteins in the form of chromatin. 9) Understand gene mapping and its significance, including how genes are mapped both genetically and physically. 10) Be able to describe changes in chromosome structure and number and describe the significance of these changes. 11) Describe genetic variation in populations as well as the factors which effect this variation. 12) Understand the nature of continuously varying traits. 13) Acquire laboratory skills and gain the ability to make adjustments in laboratory protocols as needed. Collect, analyze and present data scientifically.


As a result of completing the course, the student will: 1) Know the terminology of microbial and eukaryotic molecular genetics, and be able to recognize and apply this terminology in written exams, class discussion sessions, and reading and writing assignments) 2) Know the fundamental concepts of molecular genetics and be able to describe and apply those concepts in written exams, class discussion sessions, and reading and writing assignments) 3) Know historical and contemporary approaches used to achieve our current understanding of molecular genetics and be able to describe and apply those approaches in written exams and class discussion sessions 4) Be aware of current gaps in our understanding of molecular genetics and be able to identify these gaps in written exams 5) Be able to read research articles and write manuscript reviews that are professional


week LECTURE 1 Mitosis and meiosis, mendelian genetics 2 Modification of mendelian genetics 3 Sex determination and differentiation 4 Linkage recombination and chromosome mapping 5 Variations in chromosome number an arrangement First Hour Exam 25% 6 The genetic material 7 DNA, structure and analysis 8 DNA, replication, synthesis and replication 9 The genetic code and transcription 10 Translation Second Hour Exam 25% 11 12 Genes and proteins. Mutation and mutagenesis. Genetics of bacteria and viruses. 13 Control of Gene Expression in Prokaryotes 14 & 15 Molecular Genetics: Blotting and Probing,: Applications of Recombinant DNA Applications of Recombinant DNA Technology 16 Final Exam Electronic Forms of Communication. In accordance with College policy, I will use course container to communicate with you about all course-related matters.