Cell Biology

Course Code:

24321

Course Outline:

Credit: lecture 3 hrs.

Text Book: The World of the Cell, 7^thed (2009), by Becker, Kleinsmith, Harden and Bertoni

Course description: This course is concerned primarily with eukaryotic cells. Lectures are devoted to structural details and the molecular functions of the different parts of the cell. Lectures will introduce topics such as endocytosis, intramembrane transport, protein targeting, organelle biosynthesis, protein sorting, exocytosis, cell shape, motility, and cell-to-cell interaction. In addition, lectures will deal with signal transduction processes, cell cycle, mitosis, cancer and cellular functions that are required for cell growth and programmed cell death. By its completion, students should have a comprehensive understanding of the architecture and function of living cells.

Course Objectives.

♦ Become familiar with the various sub-cellular structures and organelles inside eukaryotic cells

♦ Understand how proteins and lipids are synthesized, transported and degraded

♦ Learn about vesicular trafficking, endocytosis and exocytosis

♦ Gain an introduction to cellular signal transduction mechanisms (also known as cell signaling)

♦ Become familiar with the molecular structure and behaviors of the cytoskeleton

♦ Understand the basic events of the cell cycle and the importance of programmed cell death (apoptosis)

♦ Gain an appreciation for the relevance of cell biology to human medical practices

Class Schedule

Week	Reading material	Topic	Pages
1	Chapter 3	The Macromolecules of the cell	41
2	Chapter 4	Cell and organelles	75
	Chapter 6	Enzymes the catalysts of life	129
3	Chapter 7	Membranes: Their structure, function and chemistry	156
4	Chapter 8	Transport across membranes: overcoming the permeability barrier	194
	Chapter 9	Chemotrophic energy metabolism: glycolysis and fermentation	224
5	Chapter 9	Chemotrophic energy metabolism: glycolysis and fermentation	224
	Chapter 10	Chemotrophic energymetabolism: aerobic respiration	252
		First exam
6	Chapter 12	Endomembrane system and peroxisomes	324
7	Chapter 12	Endomembrane system and peroxisomes	324
	Chapter 13	Signal transduction mechanisms I. Electrical signals in neurons	365
8	Chapter 13	Signal transduction mechanisms I. electrical signals in neurons	365
	Chapter 14	Signal transduction mechanisms II. Messengers and receptors	392
9	Chapter 14	Signal transduction mechanisms II. Messengers and receptors	392
10	Chapter 16	Cellular movement, motility and contractility	452
		Second exam
	Chapter 17	Beyond the cell: cell adhesion, cell junctions and extracellular structures	480
11	Chapter 17	Beyond the cell: cell adhesion, cell junctions and extracellular structures	480
12	Chapter 18	The structural basis of cellular information: DNA, chromosomes and nucleus	508
	Chapter 19	The cell cycle: DNA replication and mitosis	551
13	Chapter 19	The cell cycle: DNA replication and mitosis	551
14	Chapter 24	Cancer cells	757
15	Chapter 24	Cancer cells	757
16		Review and final exam

References:

Becker, Kleinsmith, and Hardin, 2006. The World of the Cell, 6^thed. Pearson Benjamin Cummings.
Becker, Kleinsmith, and Hardin, 2004. The World of the Cell, 5^thed. Pearson Benjamin Cummings.
Gerald Karp, 2008. Cell and molecular Biology; concepts and experiments, 5^thed. John Wiley and sons.
Alberts et al, 2004. Essential Cell Biology, 2^nded. Garland Science.
Pollard, T.D. and Earnshaw, W.C. 2002.Cell Biology, 1^sted. Elsevier Science (USA).
Lodish, H. et al. 2002. Molecular Cell Biology, 4^thed. New York: Freeman and Company.
Cooper,G. M., 2000. The Cell: A molecular approach. 2^nded. Washington, D. C. ASM press.

Assessment and Evaluation

First Exam 20%

Second Exam 20%

Assignments 10%

Final Exam 50%

Total 100%

An-Najah Staff

Author Information