Context: Despite several pharmacological applications of the medicinal
plants in the Traditional Arabic Palestinian Herbal Medicine in
Palestine (TAPHM), studies on their antioxidant properties are yet
scarce.
Objective: This work evaluates the antioxidant and anti-tumor activities
of the ethanol extracts from different parts of six plants: (Arum
palaestinum Boiss (Araceae), Urtica pilulifera L. (Urticaceae),
Coridothymus capitatus (L.) Reichb ( Lamiaceae), Majorana syriaca (L.)
Rafin. (Lamiaceae), Teucrium creticum L. (Lamiaceae), Teucrium capitatum
L. (Lamiaceae), used in the TAPHM.
Materials and methods: The antioxidant activity was evaluated for the
ethanol extracts by DPPH and β-carotene-linoleic acid assays together
with total contents of phenols and flavonoids. For the anti-carcinogenic
evaluation, the extracts were tested for the ability to inhibit the
proliferation of breast cancer cells (MCF-7) using the MTT reduction
assay
Results: Among the extracts, the U. pilulifera had the highest amount of
total phenolics, possessing the second highest total flavonoids. It
also showed a maximum cytotoxic activity (IC50 = 63 µg/ ml), followed by
C. capitatus, and A. palaestinum. Otherwise, the extract of T. creticum
has demonstrated to be an efficient scavenger of O2 (IC50= 90 µg/ml),
followed by C. capitatus, T. capitatum, A. palaestinum, and U.
pilulifera.
Discussion and conclusion: The results suggest that the investigated
plants have shown varied antioxidant capacities which were strongly
correlated with their contents of phenolics. Accordingly, this study
proposes that the therapeutic benefit of these plants can be, at least
in part, attributed to its potential inhibition of oxidative processes.
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