There is a lack of experimental and theoretical studies that address the plastic moment-shear (M-V) interaction capacity curves under fire conditions. The current paper presents a numerical study investigating the effect of fire exposure on the plastic M-V capacity curves of doubly-symmetric, wide-flanged (WF), hot-rolled steel sections. Validated finite element (FE) models to test this effect were constructed using ANSYS. Also, a simplified plastic sectional analysis, intended to be used by engineering practitioners, is proposed for generating the plastic M-V interaction curves. The comparative study shows that the fire-induced non-uniform heating of the section plates affects the shape of the plastic M-V interaction capacity curves. The study also shows that the approach for M-V interaction adopted in the Eurocode is very conservative at room-temperature, but turns out to be barely sufficiently conservative under fire conditions.