Two-dimensional NMR | An-Najah Staff

Two Dimensional NMR Studies of Marine Natural Products. III.1 Reassignment of the 13C-NMR Spectrum of Brianthein-X Using Heteronuclear Relayed Coherence Transfer

Thu, 2014-01-30 11:05 — Mohammad Musmar

Journal Title, Volume, Page:

Spectroscopy Letters: An International Journal for Rapid Communication Volume 19, Issue 5, 1986

Year of Publication:

1986

Link:

http://www.tandfonline.com/doi/abs/10.1080/00387018608069261#preview

Authors:

Gary S. Linzac

Department of Medicinal Chemistry , College of Pharmacy University of Houston-University , Park Houston, Texas, 77004

M. J. Musmar

Department of Medicinal Chemistry , College of Pharmacy University of Houston-University , Park Houston, Texas, 77004

Current Affiliation:

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

[email protected]

Alfred J. Weinheimer

Department of Medicinal Chemistry , College of Pharmacy University of Houston-University , Park Houston, Texas, 77004

Gary E. Martin

Department of Medicinal Chemistry , College of Pharmacy University of Houston-University , Park Houston, Texas, 77004

James A. Matson

Pharmaceutical Research and Development Bristol Meyers Corporation , Syracuse, New York, 13201

Preferred Abstract (Original):

During an investigation of the diterpene constituents of Briareum asbestinum we isolated the previously reported brianthein-X. Through the use of two-dimensional heteronuclear chemical shift correlation and relayed coherence transfer, four of the previously reported ¹³C-resonance assignments are revised.

Benzo[b]Phenanthro[4,3-d]Thiophene: Spectral Assignment by two-dimensional NMR Methods and Tertiary Structure Determination

Sun, 2014-01-26 13:06 — Mohammad Musmar

Journal Title, Volume, Page:

Magnetic Resonance in Chemistry Volume 24, Issue 12, pages 1039–1043, December 1986

Year of Publication:

1986

Link:

http://onlinelibrary.wiley.com/doi/10.1002/mrc.1260241206/abstract

Authors:

M. J. Musmar

Department of Medicinal Chemistry, College of Pharmacy, University of Houston—University Park, Houston, Texas 77004, USA

Current Affiliation:

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

[email protected]

Andrew S. Zektzer

Department of Medicinal Chemistry, College of Pharmacy, University of Houston—University Park, Houston, Texas 77004, USA

Gary E. Martin

Department of Medicinal Chemistry, College of Pharmacy, University of Houston—University Park, Houston, Texas 77004, USA

Robert T. Gampe Jr.

Drug Discovery Group, Abbott Laboratories, Abbott Park, Illinois 60064, USA

Milton L. Lee

Department of Chemistry, Brigham Young University, Provo, Utah 84602, USA

Marvin L. Tedjamulia

Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA

Raymond N. Castle

Department of Chemistry, University of South Florida, Tampa, Florida 33620, USA

Ralph E. Hurd

General Electric NMR Instruments, 255 Fourier Avenue, Fremont, California 94539, USA

Preferred Abstract (Original):

Two-dimensional heteronuclear chemical shift correlation, heteronuclear relayed coherence transfer and autocorrelated ¹³C—¹³C double quantum coherence have been used to assign the proton and ¹³C NMR spectra of benzo[b]phenanthro[4,3-d]thiophene. The highly complementary nature of the heteronuclear relay and carbon–carbon double quantum spectra conveniently provides the means of avoiding breaks in the carbon–carbon connectivity network assembled by the latter, which may arise when strongly AB rather than AX carbon–carbon pairings are encountered. Nuclear Overhauser difference spectra have shown the title compound to possess a tertiary helical structure similar to that of phenanthro[3,4-b]thiophene; the average separation between the H-1 and H-13 atoms of the title compound was found to be 2.06 ± 0.04 Å.