polarography | An-Najah Staff

Electrochemical Reduction and Determination of Azathioprine

Wed, 2014-07-09 09:54 — Raqi Mohammad Hasan Shubietah

Journal Title, Volume, Page:

Magazine of Scientific Research, Volume(1)‎

Year of Publication:

1999

Link:

http://www.alazhar.edu.ps/journal123/detailsr.asp?seqq1=813

Authors:

R. M. Shubietah

Current Affiliation:

Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine

[email protected]

A. Z. Abu Zuhri

A. G. Fogg

Preferred Abstract (Original):

Sensitive method for the determination of azathioprine by differential-pulse polarography (DPP) is described . The cyclic voltammograms demonstrate the adsorption of the drug on the mercury electrode . The effect of different experimental parameters affecting the drug determination e.g. pH, supporting electrolyte nature, accumulation potential, accumulation time, presence of copper ions and other operational parameters are also mentioned. In pH 7.5, Britton-Robinson buffer, the calibration graph for the determination of azathioprine was linear in the range 5.0x10^-5_- 5.0x10^-7 M with RSD of 1.3. The detection limit was found to be 1.0x10^-8 M. The degree of interference from some other purines, anions and metal ions on the azathioprine peak was evaluated. The method was applied to the determination of drug in commercially available dosage forms.

Polarographic Behaviour of ‎Salicylaldehyde-2-Pyridylhydrazone and ‎its Copper(II) Complex

Wed, 2014-03-26 13:02 — Maher An-Natsheh

Journal Title, Volume, Page:

Microchimica Acta, Volume 92, Issue 4-6, pp 153-161

Year of Publication:

1987

Link:

http://link.springer.com/article/10.1007%2FBF01201835

Authors:

Maher A. Abu-Eid

Chemistry Department, An-Najah National University, P. O. Box 7, Nablus, Palestine

Current Affiliation:

Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine

[email protected]

Jamal S. Shalabi

Chemistry Department, An-Najah National University, P. O. Box 7, Nablus, Palestine

Ali Z. Abu Zuhri

Chemistry Department, An-Najah National University, P. O. Box 7, Nablus, Palestine

Preferred Abstract (Original):

The polarographic behaviour of salicylaldehyde-2-pyridylhydrazone (SAPH) has been studied in aqueous buffer solution containing 40% ethanol using DC and DP polarographic methods. In the pH range 1.8–7.5 the observed single irreversible reduction wave is assigned to the splitting of the N-N bond and reduction of C=N centre. In alkaline medium, a second wave appears at a more negative potential due to the reduction of the salicylaldehyde which is formed by hydrolytic decomposition of the SAPH molecule. The effect of pH on the limiting current andE 1/2 as well as the reduction mechanism are discussed and compared with similar compounds. The kinetic parameters of the electrode reaction have been calculated.

The analytical properties of the copper(II)-SAPH system is described. The complex gave rise to a single irreversible well-defined wave (E 1/2=−0.58 V at pH=5.2). The reaction process is diffusion controlled. A method is suggested for the determination of Cu(II) in presence of different metal ions as the difference in theirE 1/2 values is sufficient for the purpose.