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Determination of Aminophylline by Cathodic Stripping Voltammetry

Thu, 2013-02-14 12:21 — Raqi Mohammad Hasan Shubietah
Journal Title, Volume, Page: 
An-Najah University Journal for Research - Natural Sciences - Volume 15, Issue 1, 2001
Year of Publication: 
2001
Link: 
http://scholar.najah.edu/publication/journal-article/determination-aminophylline...
Authors: 
Raqi M. H. Shubietah
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Pharmacy, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, Palestine
[email protected]
Preferred Abstract (Original): 

Aminophylline is determined by cathodic stripping voltammetry (CSV) in BR buffer, pH 7.5 at a hanging mercury drop electrode. The detection limit was 3x108- M after 60 s accumulation at -0.60 V versus Ag/AgCl reference electrode. The linear range demonstrated up to 5x107-M using CSV. The interference caused by some purine derivatives, anions and some metal cations on the peak current was studied. The peak current is enhanced by theophylline, some methylguanines and copper (II) while it decreased or disappeared by citrate, chloride and Triton X-100 surfactant. The method has good sensitivity and its application to pharmaceutical samples is possible.

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