Asymmetric synthesis

Journal Title, Volume, Page:

Tetrahedron Letters 53(22), 2699-2701

Year of Publication:

2012

Link:

http://www.sciencedirect.com/science/article/pii/S0040403912004819

Authors:

Hamed, Othman A

Department of Chemistry, An-Najah National University, PO Box 7, Nablus, Palestine

Current Affiliation:

Department of Chemistry, An-Najah National University, PO Box 7, Nablus, Palestine

[email protected]

Arab El-Qisairi

Department of Chemistry, Mu’tah University, PO Box 7, Mu’tah-Karak, Jordan

Hanan Qaseer

Department of Chemistry, Mu’tah University, PO Box 7, Mu’tah-Karak, Jordan

Emad M. Hamed

Department of Chemistry, University of Guelph, Ontario, Canada N1G 2W1

Patrick M. Henry

Department of Chemistry, Loyola University Chicago, 6525 N. Sheridan Road, Chicago, IL 60626, USA

Daniel P. Becker

Department of Chemistry, Loyola University Chicago, 6525 N. Sheridan Road, Chicago, IL 60626, USA

Preferred Abstract (Original):

The oxidation of ketones by a chiral bimetallic palladium(II) complex in the presence of CuCl₂ in THF–water solvents gave an enantioselective synthesis of α-hydroxyketones in catalytic oxidation utilizing an atmosphere of oxygen. The ee’s ranged from 61% to 92%. The reaction was accelerated by addition of strong acid that presumably increases the rate of enolization.

An-Najah Staff

Asymmetric α -Hydroxy Ketone Synthesis by Direct Ketone Oxidation Using a Bimetallic Palladium(II) Complex