Synthesis and characterization of novel 2,2-di(pyridin-2-yl) hexahydropyrimidine and its derivative5,5-dimethyl-1,3- bis[(methylsulfonyl)oxy]-2,2-dipyridin-2-ylhexahydropyrimidine

Journal Title, Volume, Page:

Der Pharma Chemica, 2015, 7(6):299-304

Year of Publication:

2015

Authors:

Mohammed Suleiman 1 *, Lamees Odeh 1 , Rachid Salghi 2 , Smaail Radi , Belkheir Hammouti 3 , Anas Al-Ali 1 , Ismail Warad 1* 3

Preferred Abstract (Original):

2,2-di(pyridin-2-yl) hexahydropyrimidine heterocyclic compound was prepared by condensation reaction of 1,3propanediaminewith

di(pyridin-2-yl)methanone1.5,5-dimethyl-1,3-bis[(methyl sulfonyl)oxy]-2,2-dipyridin-2ylhexahydropyrimidine2

was prepared by protection of both N-H groups in2 using MeSO

Cl reagent in

pyridine/THF media.The prepared compounds revealed good thermal stability, and simple one step decomposition

mechanism. The condensation reaction to prepare 1has been monitored by IR.The structures of the desired

compounds were characterized by elemental analysis, EI-Ms, UV-Vis, FT-IR, TG and NMR.

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