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POM Theoretical Calculations and Experimental Verification of The Antibacterial Potential of 5-Hydroxy-4-(Substituted-Amino)-2(5H)-Furanones

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Sun, 2013-04-14 08:10 — Ismail Warad
Journal Title, Volume, Page: 
Research on Chemical Intermediates May 2013, Volume 39, Issue 5, pp 1963-1971
Year of Publication: 
2013
Link: 
http://link.springer.com/article/10.1007%2Fs11164-012-0729-0
Authors: 
Taibi B. Hadda
Laboratoire Chimie Matériaux, Faculté Sciences, Université Med Premier, Oujda, Morocco
[email protected]
Teffaha Fergoug
Laboratoire de Chimie Physique des Biomolécules et Interfaces Biologiques, Faculté des Sciences de la Nature et de la Vie, Université de Mascara, 29000, Mascara, Algérie
Ismail Warad
Department of Chemistry, Science College, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
[email protected]
Preferred Abstract (Original): 
The structure and antibacterial activity of previously synthesized and tested compounds 4-amino-5-hydroxy 2(5H)-furanones 2a–h have been investigated. These compounds have previously been screened against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, and Pseudomonas aeruginosa ATCC 27853. Here we report results from POM analysis of their interaction with bacterial targets. The structure and governing force of the antibacterial pharmacophore site of furanones 2a–h were established on the basis of a hypothetical and semi-empirical antibacterial (Xδ+–Yδ−) pharmacophore site.