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Molecular structure investigation and Biological Evaluation of Michael Adducts Derived from Dimedone

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Thu, 2015-09-17 10:04 — Ismail Warad
Journal Title, Volume, Page: 
Research on Chemical Intermediates · August 2015
Year of Publication: 
2015
Authors: 
Assem Barakat
Department of Chemistry College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia
Abdullah Al Majid
Department of Chemistry College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia
Mohammad Shahidul Islam
Department of Chemistry College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi Arabia
Ismail Warad
Department of Chemistry, Science College, Al-Najah National University, PO Box 7, Nablus, Palestine
Vijay H. Masand
Department of Chemistry, Vidya Bharati College, Amravati, Maharashtra 444 602, India
Sammer Yousuf
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
Preferred Abstract (Original): 
Trimolecular salt Michael adducts 2a-c were synthesized in excellent yields up to 92% via one pot multicomponent reactions in aqueous medium. The chemical structures of compounds 2a-c were characterized by X-ray single-crystal diffraction techniques. Calculations of the density functional theory (DFT) for the synthesized compound were performed. The stability of the products was deduced by TGA analysis. Compounds 2a-c were screened in vitro for different bio-assays such as thymidine phosphorylase inhibition assay, urease inhibition assay, ß-glucuronidase inhibition assays and cytotoxicity against PC-3 and Hela cell lines.
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