An-Najah Staff
Home
Forums
Groups
Recent posts
Log in
Author Information
Ismail Warad
Offline
Last seen:
8 years 11 weeks ago
Joined:
2012-12-16
Search this site:
Home
›
warad
›
Publications
›
Published Researches
Molecular structure investigation and biological evaluation of Michael adducts derived from dimedone
Wed, 2015-10-28 09:33 —
Ismail Warad
Journal Title, Volume, Page:
Res Chem Intermed
Year of Publication:
2015
Authors:
Assem Barakat , Abdullah M. Al-Majid Mohammad Shahidul Islam Vijay H. Masand M. Iqbal Choudhary , Ismail Warad , Sammer Yousuf
Preferred Abstract (Original):
Trimolecular salt Michael adducts 2a–c were synthesized in excellent
yields up to 92 % via one-pot multicomponent reactions in an aqueous medium. The
chemical structures of compounds 2a–c were characterized by X-ray single-crystal
diffraction techniques. Calculations of the density functional theory for the synthesized
compound were performed. The stability of the products was deduced by
TGA analysis. Compounds 2a–c were screened in vitro for different bio-assays such
as thymidine phosphorylase inhibition assay, urease inhibition assay, b-glucuronidase
inhibition assays and cytotoxicity against PC-3 and HeLa cell lines.
Michael adduct Dimedone Thymidine phosphorylase assay Urease inhibition assay b-Glucuronidase inhibition assay
276 reads
Facebook
Google
LinkedIn
Twitter