Identification of Pharmacophore Site of Armed Quinoxaline, Benzothiazole and Benzothiazine: POM Theoretical Screening and Experimental Evaluation of Antifungal and Antibacterial Activity

Journal Title, Volume, Page:

Journal of Medicinal Chemistry and Drug Discovery 13 (2013) 313 – 322

Year of Publication:

2013

Link:

http://www.jmcdd.org/

Authors:

Taibi Ben Hadda

Laboratoire de Chimie des Matériaux, Faculté des Sciences, 60000 Oujda, Morocco

Fatim - Zahra. Khardl

Laboratoire de Chimie des Matériaux, Faculté des Sciences, 60000 Oujda, Morocco

Mostafa Mimouni

Laboratoire de Chimie des Matériaux, Faculté des Sciences, 60000 Oujda, Morocco

Maria Daoudi

Laboratoire Chimie Organique, Faculté des Sciences Dhar Mehraz, 30000 Fès, Morocco

Abdelali Kerbal

Laboratoire Chimie Organique, Faculté des Sciences Dhar Mehraz, 30000 Fès, Morocco

Brahim Bennani

Laboratoire Chimie Organique, Faculté des Sciences Dhar Mehraz, 30000 Fès, Morocco

Ismail Warad

Department of Chemistry, Science College. King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia

Current Affiliation:

Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine

[email protected]

Héctor Salgado - Zamora

Departamento de Química Orgánica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Col. Santo Tomás 11340, México, D. F

Teffaha Fergoug

Laboratoire de Chimie Physique des Biomolécules et Interfaces biologiques, Faculté des Sciences de la Nature et de la Vie, Université de Mascara, Mascara 29000, Algérie

Preferred Abstract (Original):

A series of four different armed heterocyclic candidates; the 1 - (2 - methyl - 2,3 - dihydro - 1,3 - benzothiazol - 2 - yl)acetone ( 2 ), 1 - (3 - methyl - 4 H - 1,4 - benzothiazin - 2 - yl)ethanone ( 3 ), 2 - [(2 - aminophenyl)dithio]aniline ( 4 ) and 3 - hydroxy - 3 - methyl - 4 - (3 - methyl - 2 - quinoxalinyl) - 2 - butanone ( 5 ) have been prepared and their antibacterial and antifungal activity were evaluated.

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Identification of Pharmacophore Site of Armed Quinoxaline, Benzothiazole and Benzothiazine: POM Theoretical Screening and Experimental Evaluation of Antifungal and Antibacterial Activity