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DNA Binding test, X-Ray Crystal Structure, Spectral, TG-DTA, and Electrochemistry of [CoX2(dmdphphen)] (dmdphphen is 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline, X= Cl and NCS) Complexes

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Tue, 2015-01-13 15:16 — Ismail Warad
Journal Title, Volume, Page: 
Bioinorganic Chemistry and Applications, 12/2014
Year of Publication: 
2014
Authors: 
Mousa Z Al-Noaimi
Depart ment of Chemistry, Hashemite University, Zarqa 13115, Jordan
Hany W. Darwish
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Mohammed Suleiman
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Ahmed H. Bakheit
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Muneer Abdoh
Department of Physics, Faculty of Sciences, An-Najah National University, Nablus, Palestine
Iyad Saadeddin
Department of Physics, Faculty of Sciences, An-Najah National University, Nablus, Palestine
Naveen S
Institution of Excellence, Vijnana Bhavana, University of Mysore, Manasagangotri, Mysore 570 006, India
Neartur Krishnappagowda Lokanath
Department of Studies in Physics, University of Mysore, Manasagangotri, Mysore 570 006, India
Odey Bsharat
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Assem Barakat
Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
Ismail Warad
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
Current Affiliation: 
Department of Chemistry, Faculty of Science, An-Najah National University, Nablus, Palestine
[email protected]
Preferred Abstract (Original): 

Two new neutral mixed-ligand cobalt(II) complexes, [CoCl2(dmdphphen)] 1and [Co(NCS)2(dmdphphen)] 2 where dmdphphen is 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline, were synthesized and characterized by an elemental analysis, UV-Vis, IR, TG/DTA, cyclic voltametry CV and single X-ray diffraction. Complex 2 crystallized as monoclinic with a space group P21/c. Co(II) ions are located in a distorted tetrahedral environment. TG/DTA result shows that these complexes are very stable and decomposed through one step reaction. The two complexes exhibit a quasi-reversible one electron response at-550 and 580mV vs. Cp2Fe/Cp2Fe+, which has been assigned to Co(I)/Co(II) and Co(II)/Co(III) couples. Absorption spectral studies reveal that the such complexes exhibit hypochromicity during their interaction with CT-DNA.

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DNA_Binding_test,_X-Ray_Crystal_Structure,_Spectral,_TG-DTA,_and_Electrochemistry_of_[CoX2(dmdphphen)]_(dmdphphen_is_2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline,_X=_Cl_and_NCS)_Complexes.pdf519.23 KB